Abstract
Oxidative stress has been related to various diseases, gender and ageing, and has been measured by various markers. The authors developed a procedure to compute a global oxidative stress index (OXY-SCORE), reflecting both oxidative and antioxidant markers in healthy subjects. Its performance was tested in relation to age and gender and in coronary artery disease (CAD) patients. Eighty-two healthy subjects and 20 CAD patients were enrolled. Plasma free and total malondialdehyde (F- and T-MDA), glutathione disulphide/reduced form ratio (GSSG/GSH) and urine isoprostanes (iPF2α-III) levels were combined as oxidative damage markers (damage score). GSH, α- and γ-tocopherol (TH) levels, and individual antioxidant capacity were combined as antioxidant defence indexes (protection score). The OXY-SCORE was computed by subtracting the protection score from the damage score. Among single parameters, T-MDA and iPF2α -III significantly correlated with age; only GSH and both tocopherols correlated with male gender in healthy subjects. The OXY-SCORE was positively associated with age (p = 0.004) and male gender (p = 0.03). As expected, the OXY-SCORE was higher in CAD with a very significant p-value (
| Original language | English |
|---|---|
| Pages (from-to) | 562-573 |
| Number of pages | 12 |
| Journal | Biomarkers |
| Volume | 11 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Nov 2006 |
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Keywords
- Ageing
- Coronary artery disease (CAD)
- Oxidative stress markers
- Pro/antioxidant global indices
ASJC Scopus subject areas
- Biotechnology
- Toxicology
Cite this
Age- and gender-related oxidative status determined in healthy subjects by means of OXY-SCORE, a potential new comprehensive index. / Veglia, F.; Cighetti, G.; De Franceschi, M.; Zingaro, L.; Boccotti, L.; Tremoli, E.; Cavalca, V.
In: Biomarkers, Vol. 11, No. 6, 11.2006, p. 562-573.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age- and gender-related oxidative status determined in healthy subjects by means of OXY-SCORE, a potential new comprehensive index
AU - Veglia, F.
AU - Cighetti, G.
AU - De Franceschi, M.
AU - Zingaro, L.
AU - Boccotti, L.
AU - Tremoli, E.
AU - Cavalca, V.
PY - 2006/11
Y1 - 2006/11
N2 - Oxidative stress has been related to various diseases, gender and ageing, and has been measured by various markers. The authors developed a procedure to compute a global oxidative stress index (OXY-SCORE), reflecting both oxidative and antioxidant markers in healthy subjects. Its performance was tested in relation to age and gender and in coronary artery disease (CAD) patients. Eighty-two healthy subjects and 20 CAD patients were enrolled. Plasma free and total malondialdehyde (F- and T-MDA), glutathione disulphide/reduced form ratio (GSSG/GSH) and urine isoprostanes (iPF2α-III) levels were combined as oxidative damage markers (damage score). GSH, α- and γ-tocopherol (TH) levels, and individual antioxidant capacity were combined as antioxidant defence indexes (protection score). The OXY-SCORE was computed by subtracting the protection score from the damage score. Among single parameters, T-MDA and iPF2α -III significantly correlated with age; only GSH and both tocopherols correlated with male gender in healthy subjects. The OXY-SCORE was positively associated with age (p = 0.004) and male gender (p = 0.03). As expected, the OXY-SCORE was higher in CAD with a very significant p-value (
AB - Oxidative stress has been related to various diseases, gender and ageing, and has been measured by various markers. The authors developed a procedure to compute a global oxidative stress index (OXY-SCORE), reflecting both oxidative and antioxidant markers in healthy subjects. Its performance was tested in relation to age and gender and in coronary artery disease (CAD) patients. Eighty-two healthy subjects and 20 CAD patients were enrolled. Plasma free and total malondialdehyde (F- and T-MDA), glutathione disulphide/reduced form ratio (GSSG/GSH) and urine isoprostanes (iPF2α-III) levels were combined as oxidative damage markers (damage score). GSH, α- and γ-tocopherol (TH) levels, and individual antioxidant capacity were combined as antioxidant defence indexes (protection score). The OXY-SCORE was computed by subtracting the protection score from the damage score. Among single parameters, T-MDA and iPF2α -III significantly correlated with age; only GSH and both tocopherols correlated with male gender in healthy subjects. The OXY-SCORE was positively associated with age (p = 0.004) and male gender (p = 0.03). As expected, the OXY-SCORE was higher in CAD with a very significant p-value (
KW - Ageing
KW - Coronary artery disease (CAD)
KW - Oxidative stress markers
KW - Pro/antioxidant global indices
UR - http://www.scopus.com/inward/record.url?scp=33750338702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750338702&partnerID=8YFLogxK
U2 - 10.1080/13547500600898623
DO - 10.1080/13547500600898623
M3 - Article
C2 - 17056475
AN - SCOPUS:33750338702
VL - 11
SP - 562
EP - 573
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 6
ER -