Age- and gender-related oxidative status determined in healthy subjects by means of OXY-SCORE, a potential new comprehensive index

F. Veglia, G. Cighetti, M. De Franceschi, L. Zingaro, L. Boccotti, E. Tremoli, V. Cavalca

Research output: Contribution to journalArticlepeer-review

Abstract

Oxidative stress has been related to various diseases, gender and ageing, and has been measured by various markers. The authors developed a procedure to compute a global oxidative stress index (OXY-SCORE), reflecting both oxidative and antioxidant markers in healthy subjects. Its performance was tested in relation to age and gender and in coronary artery disease (CAD) patients. Eighty-two healthy subjects and 20 CAD patients were enrolled. Plasma free and total malondialdehyde (F- and T-MDA), glutathione disulphide/reduced form ratio (GSSG/GSH) and urine isoprostanes (iPF-III) levels were combined as oxidative damage markers (damage score). GSH, α- and γ-tocopherol (TH) levels, and individual antioxidant capacity were combined as antioxidant defence indexes (protection score). The OXY-SCORE was computed by subtracting the protection score from the damage score. Among single parameters, T-MDA and iPF -III significantly correlated with age; only GSH and both tocopherols correlated with male gender in healthy subjects. The OXY-SCORE was positively associated with age (p = 0.004) and male gender (p = 0.03). As expected, the OXY-SCORE was higher in CAD with a very significant p-value (

Original languageEnglish
Pages (from-to)562-573
Number of pages12
JournalBiomarkers
Volume11
Issue number6
DOIs
Publication statusPublished - Nov 2006

Keywords

  • Ageing
  • Coronary artery disease (CAD)
  • Oxidative stress markers
  • Pro/antioxidant global indices

ASJC Scopus subject areas

  • Biotechnology
  • Toxicology

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