Age- and gender-related oxidative status determined in healthy subjects by means of OXY-SCORE, a potential new comprehensive index

F. Veglia, G. Cighetti, M. De Franceschi, L. Zingaro, L. Boccotti, E. Tremoli, V. Cavalca

Research output: Contribution to journalArticle

Abstract

Oxidative stress has been related to various diseases, gender and ageing, and has been measured by various markers. The authors developed a procedure to compute a global oxidative stress index (OXY-SCORE), reflecting both oxidative and antioxidant markers in healthy subjects. Its performance was tested in relation to age and gender and in coronary artery disease (CAD) patients. Eighty-two healthy subjects and 20 CAD patients were enrolled. Plasma free and total malondialdehyde (F- and T-MDA), glutathione disulphide/reduced form ratio (GSSG/GSH) and urine isoprostanes (iPF-III) levels were combined as oxidative damage markers (damage score). GSH, α- and γ-tocopherol (TH) levels, and individual antioxidant capacity were combined as antioxidant defence indexes (protection score). The OXY-SCORE was computed by subtracting the protection score from the damage score. Among single parameters, T-MDA and iPF -III significantly correlated with age; only GSH and both tocopherols correlated with male gender in healthy subjects. The OXY-SCORE was positively associated with age (p = 0.004) and male gender (p = 0.03). As expected, the OXY-SCORE was higher in CAD with a very significant p-value (

Original languageEnglish
Pages (from-to)562-573
Number of pages12
JournalBiomarkers
Volume11
Issue number6
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Coronary Artery Disease
Healthy Volunteers
Tocopherols
Glutathione Disulfide
Antioxidants
Oxidative stress
Oxidative Stress
Isoprostanes
Malondialdehyde
Urine
Aging of materials
Plasmas

Keywords

  • Ageing
  • Coronary artery disease (CAD)
  • Oxidative stress markers
  • Pro/antioxidant global indices

ASJC Scopus subject areas

  • Biotechnology
  • Toxicology

Cite this

Age- and gender-related oxidative status determined in healthy subjects by means of OXY-SCORE, a potential new comprehensive index. / Veglia, F.; Cighetti, G.; De Franceschi, M.; Zingaro, L.; Boccotti, L.; Tremoli, E.; Cavalca, V.

In: Biomarkers, Vol. 11, No. 6, 11.2006, p. 562-573.

Research output: Contribution to journalArticle

@article{80654a0c44fd4b3aa2eb5bb8d28ca8ba,
title = "Age- and gender-related oxidative status determined in healthy subjects by means of OXY-SCORE, a potential new comprehensive index",
abstract = "Oxidative stress has been related to various diseases, gender and ageing, and has been measured by various markers. The authors developed a procedure to compute a global oxidative stress index (OXY-SCORE), reflecting both oxidative and antioxidant markers in healthy subjects. Its performance was tested in relation to age and gender and in coronary artery disease (CAD) patients. Eighty-two healthy subjects and 20 CAD patients were enrolled. Plasma free and total malondialdehyde (F- and T-MDA), glutathione disulphide/reduced form ratio (GSSG/GSH) and urine isoprostanes (iPF2α-III) levels were combined as oxidative damage markers (damage score). GSH, α- and γ-tocopherol (TH) levels, and individual antioxidant capacity were combined as antioxidant defence indexes (protection score). The OXY-SCORE was computed by subtracting the protection score from the damage score. Among single parameters, T-MDA and iPF2α -III significantly correlated with age; only GSH and both tocopherols correlated with male gender in healthy subjects. The OXY-SCORE was positively associated with age (p = 0.004) and male gender (p = 0.03). As expected, the OXY-SCORE was higher in CAD with a very significant p-value (",
keywords = "Ageing, Coronary artery disease (CAD), Oxidative stress markers, Pro/antioxidant global indices",
author = "F. Veglia and G. Cighetti and {De Franceschi}, M. and L. Zingaro and L. Boccotti and E. Tremoli and V. Cavalca",
year = "2006",
month = "11",
doi = "10.1080/13547500600898623",
language = "English",
volume = "11",
pages = "562--573",
journal = "Biomarkers",
issn = "1354-750X",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Age- and gender-related oxidative status determined in healthy subjects by means of OXY-SCORE, a potential new comprehensive index

AU - Veglia, F.

AU - Cighetti, G.

AU - De Franceschi, M.

AU - Zingaro, L.

AU - Boccotti, L.

AU - Tremoli, E.

AU - Cavalca, V.

PY - 2006/11

Y1 - 2006/11

N2 - Oxidative stress has been related to various diseases, gender and ageing, and has been measured by various markers. The authors developed a procedure to compute a global oxidative stress index (OXY-SCORE), reflecting both oxidative and antioxidant markers in healthy subjects. Its performance was tested in relation to age and gender and in coronary artery disease (CAD) patients. Eighty-two healthy subjects and 20 CAD patients were enrolled. Plasma free and total malondialdehyde (F- and T-MDA), glutathione disulphide/reduced form ratio (GSSG/GSH) and urine isoprostanes (iPF2α-III) levels were combined as oxidative damage markers (damage score). GSH, α- and γ-tocopherol (TH) levels, and individual antioxidant capacity were combined as antioxidant defence indexes (protection score). The OXY-SCORE was computed by subtracting the protection score from the damage score. Among single parameters, T-MDA and iPF2α -III significantly correlated with age; only GSH and both tocopherols correlated with male gender in healthy subjects. The OXY-SCORE was positively associated with age (p = 0.004) and male gender (p = 0.03). As expected, the OXY-SCORE was higher in CAD with a very significant p-value (

AB - Oxidative stress has been related to various diseases, gender and ageing, and has been measured by various markers. The authors developed a procedure to compute a global oxidative stress index (OXY-SCORE), reflecting both oxidative and antioxidant markers in healthy subjects. Its performance was tested in relation to age and gender and in coronary artery disease (CAD) patients. Eighty-two healthy subjects and 20 CAD patients were enrolled. Plasma free and total malondialdehyde (F- and T-MDA), glutathione disulphide/reduced form ratio (GSSG/GSH) and urine isoprostanes (iPF2α-III) levels were combined as oxidative damage markers (damage score). GSH, α- and γ-tocopherol (TH) levels, and individual antioxidant capacity were combined as antioxidant defence indexes (protection score). The OXY-SCORE was computed by subtracting the protection score from the damage score. Among single parameters, T-MDA and iPF2α -III significantly correlated with age; only GSH and both tocopherols correlated with male gender in healthy subjects. The OXY-SCORE was positively associated with age (p = 0.004) and male gender (p = 0.03). As expected, the OXY-SCORE was higher in CAD with a very significant p-value (

KW - Ageing

KW - Coronary artery disease (CAD)

KW - Oxidative stress markers

KW - Pro/antioxidant global indices

UR - http://www.scopus.com/inward/record.url?scp=33750338702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750338702&partnerID=8YFLogxK

U2 - 10.1080/13547500600898623

DO - 10.1080/13547500600898623

M3 - Article

C2 - 17056475

AN - SCOPUS:33750338702

VL - 11

SP - 562

EP - 573

JO - Biomarkers

JF - Biomarkers

SN - 1354-750X

IS - 6

ER -