Age and geographic variability of human papillomavirus high-risk genotype distribution in a large unvaccinated population and of vaccination impact on HPV prevalence

Francesca Carozzi, Laura De Marco, Anna Gillio-Tos, Annarosa Del Mistro, Salvatore Girlando, Lorena Baboci, Morena Trevisan, Elena Burroni, Stefano Grasso, Paolo Giorgi Rossi, Guglielmo Ronco, N. Segnan, R. Rizzolo, P. Giubilato, B. Ghiringhello, A. Sapino, M. G. Accinelli, G. Maina, L. Pasero, Trento P. Dalla PalmaE. Polla, Veneto H. Frayle-Salamanca, R. Trevisan, M. Zorzi, C. Fedato, S. Baracco, E. Insacco, D. Minucci, M. Matteucci, G. L. Onnis, R. Colombari, Emilia Romagna M Manfredi, G. P. Casadei, P. Pierotti, G. Collina, P. Schincaglia, M. Ser-afini, M. Vitali, M. Aldi, S. Folicaldi, R. Nannini, G. Galanti, M. De Lillo, C. Naldoni, Florence M. Confortini, A. Iossa, C. Sani, S. Ciatto, M. P. Cariaggi, S. Cecchini, M. Zappa, G. L. Taddei, Lazio S. Brezzi, P. Raggi, E. Gomes, A. Pelle-grini, M. L. Schiboni, P. Borgia, F. Chini

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: The prevalence of infections with human papillomavirus (HPV) specific genotypes differs by age and areas. Knowledge of these differences will help predicting how prophylactic HPV vaccination and screening program could best be integrated. Objectives: To investigate variations in the HPV distribution between areas and ages in Italy and the impact of vaccination on HPV prevalence. Study design: 37,367 women aged 25-60 years who attended cervical screening in eight different areas in Northern and Central Italy were tested for HPV infection with the high-risk hybrid capture (hr-HC2) assay. hr-HC2 positive samples were genotyped by an intensive integrated strategy. Results: hr-HPV types were detected in 79.1% of HC2 positive women. HPV16 was the most frequent type, followed by HPV31, HPV18 and HPV56. A statistically significant variability in HPV type distribution between centres (overall χ84df2=195.86 p

Original languageEnglish
Pages (from-to)257-263
Number of pages7
JournalJournal of Clinical Virology
Volume60
Issue number3
DOIs
Publication statusPublished - 2014

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Vaccination
Genotype
Population
Italy
Papillomavirus Infections
Infection

Keywords

  • Genotyping
  • High risk HPV
  • Human papillomavirus
  • Vaccine

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Medicine(all)

Cite this

Age and geographic variability of human papillomavirus high-risk genotype distribution in a large unvaccinated population and of vaccination impact on HPV prevalence. / Carozzi, Francesca; De Marco, Laura; Gillio-Tos, Anna; Del Mistro, Annarosa; Girlando, Salvatore; Baboci, Lorena; Trevisan, Morena; Burroni, Elena; Grasso, Stefano; Rossi, Paolo Giorgi; Ronco, Guglielmo; Segnan, N.; Rizzolo, R.; Giubilato, P.; Ghiringhello, B.; Sapino, A.; Accinelli, M. G.; Maina, G.; Pasero, L.; Dalla Palma, Trento P.; Polla, E.; Frayle-Salamanca, Veneto H.; Trevisan, R.; Zorzi, M.; Fedato, C.; Baracco, S.; Insacco, E.; Minucci, D.; Matteucci, M.; Onnis, G. L.; Colombari, R.; Manfredi, Emilia Romagna M; Casadei, G. P.; Pierotti, P.; Collina, G.; Schincaglia, P.; Ser-afini, M.; Vitali, M.; Aldi, M.; Folicaldi, S.; Nannini, R.; Galanti, G.; De Lillo, M.; Naldoni, C.; Confortini, Florence M.; Iossa, A.; Sani, C.; Ciatto, S.; Cariaggi, M. P.; Cecchini, S.; Zappa, M.; Taddei, G. L.; Brezzi, Lazio S.; Raggi, P.; Gomes, E.; Pelle-grini, A.; Schiboni, M. L.; Borgia, P.; Chini, F.

In: Journal of Clinical Virology, Vol. 60, No. 3, 2014, p. 257-263.

Research output: Contribution to journalArticle

Carozzi, F, De Marco, L, Gillio-Tos, A, Del Mistro, A, Girlando, S, Baboci, L, Trevisan, M, Burroni, E, Grasso, S, Rossi, PG, Ronco, G, Segnan, N, Rizzolo, R, Giubilato, P, Ghiringhello, B, Sapino, A, Accinelli, MG, Maina, G, Pasero, L, Dalla Palma, TP, Polla, E, Frayle-Salamanca, VH, Trevisan, R, Zorzi, M, Fedato, C, Baracco, S, Insacco, E, Minucci, D, Matteucci, M, Onnis, GL, Colombari, R, Manfredi, ERM, Casadei, GP, Pierotti, P, Collina, G, Schincaglia, P, Ser-afini, M, Vitali, M, Aldi, M, Folicaldi, S, Nannini, R, Galanti, G, De Lillo, M, Naldoni, C, Confortini, FM, Iossa, A, Sani, C, Ciatto, S, Cariaggi, MP, Cecchini, S, Zappa, M, Taddei, GL, Brezzi, LS, Raggi, P, Gomes, E, Pelle-grini, A, Schiboni, ML, Borgia, P & Chini, F 2014, 'Age and geographic variability of human papillomavirus high-risk genotype distribution in a large unvaccinated population and of vaccination impact on HPV prevalence', Journal of Clinical Virology, vol. 60, no. 3, pp. 257-263. https://doi.org/10.1016/j.jcv.2014.04.009
Carozzi, Francesca ; De Marco, Laura ; Gillio-Tos, Anna ; Del Mistro, Annarosa ; Girlando, Salvatore ; Baboci, Lorena ; Trevisan, Morena ; Burroni, Elena ; Grasso, Stefano ; Rossi, Paolo Giorgi ; Ronco, Guglielmo ; Segnan, N. ; Rizzolo, R. ; Giubilato, P. ; Ghiringhello, B. ; Sapino, A. ; Accinelli, M. G. ; Maina, G. ; Pasero, L. ; Dalla Palma, Trento P. ; Polla, E. ; Frayle-Salamanca, Veneto H. ; Trevisan, R. ; Zorzi, M. ; Fedato, C. ; Baracco, S. ; Insacco, E. ; Minucci, D. ; Matteucci, M. ; Onnis, G. L. ; Colombari, R. ; Manfredi, Emilia Romagna M ; Casadei, G. P. ; Pierotti, P. ; Collina, G. ; Schincaglia, P. ; Ser-afini, M. ; Vitali, M. ; Aldi, M. ; Folicaldi, S. ; Nannini, R. ; Galanti, G. ; De Lillo, M. ; Naldoni, C. ; Confortini, Florence M. ; Iossa, A. ; Sani, C. ; Ciatto, S. ; Cariaggi, M. P. ; Cecchini, S. ; Zappa, M. ; Taddei, G. L. ; Brezzi, Lazio S. ; Raggi, P. ; Gomes, E. ; Pelle-grini, A. ; Schiboni, M. L. ; Borgia, P. ; Chini, F. / Age and geographic variability of human papillomavirus high-risk genotype distribution in a large unvaccinated population and of vaccination impact on HPV prevalence. In: Journal of Clinical Virology. 2014 ; Vol. 60, No. 3. pp. 257-263.
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abstract = "Background: The prevalence of infections with human papillomavirus (HPV) specific genotypes differs by age and areas. Knowledge of these differences will help predicting how prophylactic HPV vaccination and screening program could best be integrated. Objectives: To investigate variations in the HPV distribution between areas and ages in Italy and the impact of vaccination on HPV prevalence. Study design: 37,367 women aged 25-60 years who attended cervical screening in eight different areas in Northern and Central Italy were tested for HPV infection with the high-risk hybrid capture (hr-HC2) assay. hr-HC2 positive samples were genotyped by an intensive integrated strategy. Results: hr-HPV types were detected in 79.1{\%} of HC2 positive women. HPV16 was the most frequent type, followed by HPV31, HPV18 and HPV56. A statistically significant variability in HPV type distribution between centres (overall χ84df2=195.86 p",
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T1 - Age and geographic variability of human papillomavirus high-risk genotype distribution in a large unvaccinated population and of vaccination impact on HPV prevalence

AU - Carozzi, Francesca

AU - De Marco, Laura

AU - Gillio-Tos, Anna

AU - Del Mistro, Annarosa

AU - Girlando, Salvatore

AU - Baboci, Lorena

AU - Trevisan, Morena

AU - Burroni, Elena

AU - Grasso, Stefano

AU - Rossi, Paolo Giorgi

AU - Ronco, Guglielmo

AU - Segnan, N.

AU - Rizzolo, R.

AU - Giubilato, P.

AU - Ghiringhello, B.

AU - Sapino, A.

AU - Accinelli, M. G.

AU - Maina, G.

AU - Pasero, L.

AU - Dalla Palma, Trento P.

AU - Polla, E.

AU - Frayle-Salamanca, Veneto H.

AU - Trevisan, R.

AU - Zorzi, M.

AU - Fedato, C.

AU - Baracco, S.

AU - Insacco, E.

AU - Minucci, D.

AU - Matteucci, M.

AU - Onnis, G. L.

AU - Colombari, R.

AU - Manfredi, Emilia Romagna M

AU - Casadei, G. P.

AU - Pierotti, P.

AU - Collina, G.

AU - Schincaglia, P.

AU - Ser-afini, M.

AU - Vitali, M.

AU - Aldi, M.

AU - Folicaldi, S.

AU - Nannini, R.

AU - Galanti, G.

AU - De Lillo, M.

AU - Naldoni, C.

AU - Confortini, Florence M.

AU - Iossa, A.

AU - Sani, C.

AU - Ciatto, S.

AU - Cariaggi, M. P.

AU - Cecchini, S.

AU - Zappa, M.

AU - Taddei, G. L.

AU - Brezzi, Lazio S.

AU - Raggi, P.

AU - Gomes, E.

AU - Pelle-grini, A.

AU - Schiboni, M. L.

AU - Borgia, P.

AU - Chini, F.

PY - 2014

Y1 - 2014

N2 - Background: The prevalence of infections with human papillomavirus (HPV) specific genotypes differs by age and areas. Knowledge of these differences will help predicting how prophylactic HPV vaccination and screening program could best be integrated. Objectives: To investigate variations in the HPV distribution between areas and ages in Italy and the impact of vaccination on HPV prevalence. Study design: 37,367 women aged 25-60 years who attended cervical screening in eight different areas in Northern and Central Italy were tested for HPV infection with the high-risk hybrid capture (hr-HC2) assay. hr-HC2 positive samples were genotyped by an intensive integrated strategy. Results: hr-HPV types were detected in 79.1% of HC2 positive women. HPV16 was the most frequent type, followed by HPV31, HPV18 and HPV56. A statistically significant variability in HPV type distribution between centres (overall χ84df2=195.86 p

AB - Background: The prevalence of infections with human papillomavirus (HPV) specific genotypes differs by age and areas. Knowledge of these differences will help predicting how prophylactic HPV vaccination and screening program could best be integrated. Objectives: To investigate variations in the HPV distribution between areas and ages in Italy and the impact of vaccination on HPV prevalence. Study design: 37,367 women aged 25-60 years who attended cervical screening in eight different areas in Northern and Central Italy were tested for HPV infection with the high-risk hybrid capture (hr-HC2) assay. hr-HC2 positive samples were genotyped by an intensive integrated strategy. Results: hr-HPV types were detected in 79.1% of HC2 positive women. HPV16 was the most frequent type, followed by HPV31, HPV18 and HPV56. A statistically significant variability in HPV type distribution between centres (overall χ84df2=195.86 p

KW - Genotyping

KW - High risk HPV

KW - Human papillomavirus

KW - Vaccine

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