Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells

Fabiola Olivieri, Massimiliano Bonafè, Liana Spazzafumo, Mirko Gobbi, Francesco Prattichizzo, Rina Recchioni, Fiorella Marcheselli, Lucia La Sala, Roberta Galeazzi, Maria Rita Rippo, Gianluca Fulgenzi, Sabrina Angelini, Raffaella Lazzarini, Anna Rita Bonfigli, Francesca Brugè, Luca Tiano, Stefano Genovese, Antonio Ceriello, Massimo Boemi, Claudio FranceschiAntonio Domenico Procopio, Roberto Testa

Research output: Contribution to journalArticle

Abstract

Circulating miR-126-3p levels were determined in 136 healthy subjects (CTRs) aged 20-90 years and 193 patients with type-2 diabetes mellitus (T2DMs) aged 40-80 years, to explore the combined effect of age and glycemic state on miR-126-3p expression. Moreover, intra/extracellular miR-126-3p levels were measured in human endothelial cells (HUVECs) undergoing senescence under normo/hyper-glycemic conditions. Plasma miR-126-3p was significantly higher in the oldest compared with the youngest CTRs (75 years; relative expression: 0.27±0.29 vs. 0.48±0.39, p=0.047). Age-based comparison between CTRs and T2DM demonstrated significantly different miR-126-3p levels only in the oldest (0.48±0.39 vs. 0.22±0.23, p

Original languageEnglish
Pages (from-to)771-787
Number of pages17
JournalAging
Volume6
Issue number9
Publication statusPublished - 2014

Keywords

  • HUVEC
  • miR-126-3p
  • Senescence
  • T2DM

ASJC Scopus subject areas

  • Ageing
  • Cell Biology
  • Medicine(all)

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  • Cite this

    Olivieri, F., Bonafè, M., Spazzafumo, L., Gobbi, M., Prattichizzo, F., Recchioni, R., Marcheselli, F., La Sala, L., Galeazzi, R., Rippo, M. R., Fulgenzi, G., Angelini, S., Lazzarini, R., Bonfigli, A. R., Brugè, F., Tiano, L., Genovese, S., Ceriello, A., Boemi, M., ... Testa, R. (2014). Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells. Aging, 6(9), 771-787.