Age and immunity

Sonya Vasto, Marco Malavolta, Graham Pawelec

Research output: Contribution to journalArticle


Longitudinal studies are defining progressive alterations to the immune system associated with increased mortality in the very elderly. Many of these changes are exacerbated by or even caused by chronic T cell stimulation by persistent antigen, particularly from Cytomegalovirus. The composition of T cell subsets, their functional integrity and representation in the repertoire are all markedly influenced by age and by CMV. How these findings relate to epidemiological, functional, genetic, genomic and proteomic studies of human T cell immunosenescence was the subject of intense debate at an international conference held just before Christmas 2005 in the Black Forest.

Original languageEnglish
Article number2
JournalImmunity and Ageing
Publication statusPublished - Feb 24 2006

ASJC Scopus subject areas

  • Immunology
  • Ageing

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