Age- and sex-dependent changes in natural killer cell activity.

C. Hu, R. Scorza Smeraldi, L. Radelli, G. Fabio, M. Vanoli, C. Zanussi

Research output: Contribution to journalArticlepeer-review

Abstract

Peripheral blood mononuclear cells (PBMC) from 40 normal individuals, 20 men and 20 women, divided according to age were evaluated for their ability to mediate natural killer (NK) cytotoxicity, using the K562 erythroleukemic cells as target. The results of a specific 51Cr release assay demonstrated that NK activity was greater in men than in women. There was a significant correlation between NK activity and the percentages of Leu 11a+ cells in younger women, but not in the other groups and no correlation between NK activity and Leu 7+ cells.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume66
Issue number4
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Immunology

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