Age- and sex-related changes of tryptophan accumulation in discrete areas of the rat brain

L. Valzelli, S. Bernasconi, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Aging is known to involve changes in the neurochemistry of catecholaminergic and serotonergic components of the brain. With regard to the serotonin precursor L-tryptophan, the experiments performed in this study show that, independently of the age and sex of the animals the greatest tryptophan uptake is constantly seen in the lower brainstem, corpora striata, amygdala-hippocampus and hemispheres. However, tryptophan accumulation by the brain is more active in some brain areas of old female rats than in those of their old male mates.

Original languageEnglish
Pages (from-to)349-358
Number of pages10
JournalPharmacological Research Communications
Volume14
Issue number4
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Age- and sex-related changes of tryptophan accumulation in discrete areas of the rat brain'. Together they form a unique fingerprint.

Cite this