Age- and sex-related features of atherosclerosis from coronary computed tomography angiography in patients prior to acute coronary syndrome: results from the ICONIC study

Edoardo Conte, Aeshita Dwivedi, Saima Mushtaq, Gianluca Pontone, Fay Y. Lin, Emma J. Hollenberg, Sang Eun Lee, Jeroen Bax, Filippo Cademartiri, Kavitha Chinnaiyan, Benjamin J.W. Chow, Ricardo C. Cury, Gudrun Feuchtner, Martin Hadamitzky, Yong Jin Kim, Andrea Baggiano, Jonathon Leipsic, Erica Maffei, Hugo Marques, Fabian PlankGilbert L. Raff, Alexander R. van Rosendael, Todd C. Villines, Harald G. Weirich, Subhi J. Al'Aref, Lohendran Baskaran, Iksung Cho, Ibrahim Danad, Donghee Han, Ran Heo, Ji Hyun Lee, Wijnand J. Stuijfzand, Heidi Gransar, Yao Lu, Ji Min Sung, Hyung Bok Park, Mouaz H. Al-Mallah, Pedro de Araújo Gonçalves, Daniel S. Berman, Matthew J. Budoff, Habib Samady, Leslee J. Shaw, Peter H. Stone, Renu Virmani, Jagat Narula, James K. Min, Hyuk Jae Chang, Daniele Andreini

Research output: Contribution to journalArticlepeer-review

Abstract

AIMS: Although there is increasing evidence supporting coronary atherosclerosis evaluation by coronary computed tomography angiography (CCTA), no data are available on age and sex differences for quantitative plaque features. The aim of this study was to investigate sex and age differences in both qualitative and quantitative atherosclerotic features from CCTA prior to acute coronary syndrome (ACS). METHODS AND RESULTS: Within the ICONIC study, in which 234 patients with subsequent ACS were propensity matched 1:1 with 234 non-event controls, our current subanalysis included only the ACS cases. Both qualitative and quantitative advance plaque analysis by CCTA were performed by a core laboratory. In 129 cases, culprit lesions identified by invasive coronary angiography at the time of ACS were co-registered to baseline CCTA precursor lesions. The study population was then divided into subgroups according to sex and age (
Original languageEnglish
Pages (from-to)24-33
Number of pages10
JournalEuropean Heart Journal Cardiovascular Imaging
Volume22
Issue number1
DOIs
Publication statusE-pub ahead of print - Aug 13 2020

Keywords

  • atherosclerosis
  • cardiac CT
  • CCTA
  • gender medicine
  • high-risk plaque features

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