Age- and sex-specific reference values for media/lumen ratio in small arteries and relationship with risk factors

Study Group on Micro- and Macrocirculation of the Italian Society of Hypertension (SIIA)

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Small-artery remodeling is an early feature of target organ damage in hypertension and retains a negative prognostic value. The aim of the study is to establish age- and sex-specific reference values for media/lumen in small arteries obtained in humans by biopsy. Data from 91 healthy individuals and 200 individuals with cardiovascular risk factors in primary prevention from 4 Italian centers were pooled. Sex-specific equations for media/lumen in the healthy subpopulation, with age as dependent variable, were calculated. These equations were used to calculate predicted media/lumen values in individuals with risk factors and Z scores. The association between classical risk factors and Z scores was then explored by multiple regression analysis. A second-degree polynomial equation model was chosen to obtain sex-specific equations for media/ lumen, with age as dependent variable. In the population with risk factors (111 men, age 50.5±14.0 years, hypertension 80.5%), media/lumen Z scores were independently associated with body mass index (standardized β=0.293, P=0.0001), total cholesterol (β=0.191, P=0.031), current smoking (β=0.238, P=0.0005), fasting blood glucose (β=0.204, P=0.003), systolic blood pressure (β=0.233, P=0.023), and female sex (β=0.799, P=0.038). A significant interaction between female sex and total cholesterol was found (β=-0.979, P=0.014). Results were substantially similar in the hypertensive subgroup. A method to calculate individual values of remodeling and growth index based on reference values was also presented. Age- and sex-specific percentiles of media/lumen in a healthy population were estimated. In a predominantly hypertensive population, media/lumen Z scores were associated with major cardiovascular risk factors, including body mass index, cholesterol, smoking, glucose, and systolic blood pressure. Significant sex differences were observed.

Original languageEnglish
Pages (from-to)1193-1200
Number of pages8
JournalHypertension
Volume71
Issue number6
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Reference Values
Arteries
Blood Pressure
Cholesterol
Body Mass Index
Smoking
Population
Hypertension
Statistical Models
Primary Prevention
Sex Characteristics
Blood Glucose
Fasting
Regression Analysis
Biopsy
Glucose
Growth

Keywords

  • Blood pressure
  • Reference values
  • Risk factors
  • Small arteries
  • Vascular remodeling

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Study Group on Micro- and Macrocirculation of the Italian Society of Hypertension (SIIA) (2018). Age- and sex-specific reference values for media/lumen ratio in small arteries and relationship with risk factors. Hypertension, 71(6), 1193-1200. https://doi.org/10.1161/HYPERTENSIONAHA.117.10634

Age- and sex-specific reference values for media/lumen ratio in small arteries and relationship with risk factors. / Study Group on Micro- and Macrocirculation of the Italian Society of Hypertension (SIIA).

In: Hypertension, Vol. 71, No. 6, 01.01.2018, p. 1193-1200.

Research output: Contribution to journalArticle

Study Group on Micro- and Macrocirculation of the Italian Society of Hypertension (SIIA) 2018, 'Age- and sex-specific reference values for media/lumen ratio in small arteries and relationship with risk factors', Hypertension, vol. 71, no. 6, pp. 1193-1200. https://doi.org/10.1161/HYPERTENSIONAHA.117.10634
Study Group on Micro- and Macrocirculation of the Italian Society of Hypertension (SIIA). Age- and sex-specific reference values for media/lumen ratio in small arteries and relationship with risk factors. Hypertension. 2018 Jan 1;71(6):1193-1200. https://doi.org/10.1161/HYPERTENSIONAHA.117.10634
Study Group on Micro- and Macrocirculation of the Italian Society of Hypertension (SIIA). / Age- and sex-specific reference values for media/lumen ratio in small arteries and relationship with risk factors. In: Hypertension. 2018 ; Vol. 71, No. 6. pp. 1193-1200.
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