Age at Menarche and Menstrual Abnormalities in Adolescence

Does it Matter? The Evidence from a Large Survey among Italian Secondary Schoolgirls

Vincenzo De Sanctis, Franco Rigon, Sergio Bernasconi, Luigi Bianchin, Gianni Bona, Mauro Bozzola, Fabio Buzi, Carlo De Sanctis, Giorgio Tonini, Giorgio Radetti, Egle Perissinotto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To explore the independent role of age at menarche on menstrual abnormalities among adolescents. Methods: The present study was a multicenter cross-sectional study on a large sample (n = 3782) of Italian girls aged 13–21 y attending secondary school who already had menarche. Girls were asked to fill in a questionnaire on menarcheal age and menstrual features during the latest three menses. The gynecological age was computed as the difference between age at the survey and the age at menarche. Main outcome measures were: prevalence of oligomenorrhea, polymenorrhea, menstrual cycle irregularity, abnormal bleeding length and dysmenorrhea. Irregularity in the recent past and since menarche was also studied. Multiple logistic models were used to identify any independent association between each abnormal feature and age at menarche or gynecological age. Adjusted ORs and 95%CI were performed. Results: After adjusting for covariates, menarcheal age was not independently associated with polymenorrhea (OR = 0.81; 95%CI 0.63–1.04), oligomenorrhea (OR = 1.16; 95%CI 0.94–1.43), menstrual cycle irregularity (OR = 0.99; 95%CI 0.86–1.14), abnormal bleeding length (OR = 0.96; 95%CI 0.87–1.06) and dysmenorrhea (OR = 1.03; 95%CI 0.85–1.24). The multivariate analysis suggests that the higher prevalence of oligomenorrhea and menstrual cycle irregularity among the girls who were older at menarche might be purely explained by their younger gynecological age. Conclusions: No evidence of any independent influence of age at menarche on menstrual abnormalities among young girls was shown by the investigation. The findings suggest that, after menarche, adolescent girls’ menstrual health should be checked to monitor the endocrine system maturation and to early intercept latent disorders becoming symptomatic.

Original languageEnglish
JournalIndian Journal of Pediatrics
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Menarche
Oligomenorrhea
Menstrual Cycle
Menstruation Disturbances
Dysmenorrhea
Hemorrhage
Endocrine System
Menstruation
Surveys and Questionnaires
Multivariate Analysis
Cross-Sectional Studies
Logistic Models
Outcome Assessment (Health Care)
Health

Keywords

  • Age at menarche
  • Dysmenorrheal
  • Gynecological age
  • Menstrual irregularity
  • Menstrual pattern
  • Schoolgirls

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Age at Menarche and Menstrual Abnormalities in Adolescence : Does it Matter? The Evidence from a Large Survey among Italian Secondary Schoolgirls. / De Sanctis, Vincenzo; Rigon, Franco; Bernasconi, Sergio; Bianchin, Luigi; Bona, Gianni; Bozzola, Mauro; Buzi, Fabio; De Sanctis, Carlo; Tonini, Giorgio; Radetti, Giorgio; Perissinotto, Egle.

In: Indian Journal of Pediatrics, 01.01.2019.

Research output: Contribution to journalArticle

De Sanctis, Vincenzo ; Rigon, Franco ; Bernasconi, Sergio ; Bianchin, Luigi ; Bona, Gianni ; Bozzola, Mauro ; Buzi, Fabio ; De Sanctis, Carlo ; Tonini, Giorgio ; Radetti, Giorgio ; Perissinotto, Egle. / Age at Menarche and Menstrual Abnormalities in Adolescence : Does it Matter? The Evidence from a Large Survey among Italian Secondary Schoolgirls. In: Indian Journal of Pediatrics. 2019.
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abstract = "Objective: To explore the independent role of age at menarche on menstrual abnormalities among adolescents. Methods: The present study was a multicenter cross-sectional study on a large sample (n = 3782) of Italian girls aged 13–21 y attending secondary school who already had menarche. Girls were asked to fill in a questionnaire on menarcheal age and menstrual features during the latest three menses. The gynecological age was computed as the difference between age at the survey and the age at menarche. Main outcome measures were: prevalence of oligomenorrhea, polymenorrhea, menstrual cycle irregularity, abnormal bleeding length and dysmenorrhea. Irregularity in the recent past and since menarche was also studied. Multiple logistic models were used to identify any independent association between each abnormal feature and age at menarche or gynecological age. Adjusted ORs and 95{\%}CI were performed. Results: After adjusting for covariates, menarcheal age was not independently associated with polymenorrhea (OR = 0.81; 95{\%}CI 0.63–1.04), oligomenorrhea (OR = 1.16; 95{\%}CI 0.94–1.43), menstrual cycle irregularity (OR = 0.99; 95{\%}CI 0.86–1.14), abnormal bleeding length (OR = 0.96; 95{\%}CI 0.87–1.06) and dysmenorrhea (OR = 1.03; 95{\%}CI 0.85–1.24). The multivariate analysis suggests that the higher prevalence of oligomenorrhea and menstrual cycle irregularity among the girls who were older at menarche might be purely explained by their younger gynecological age. Conclusions: No evidence of any independent influence of age at menarche on menstrual abnormalities among young girls was shown by the investigation. The findings suggest that, after menarche, adolescent girls’ menstrual health should be checked to monitor the endocrine system maturation and to early intercept latent disorders becoming symptomatic.",
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AU - Bianchin, Luigi

AU - Bona, Gianni

AU - Bozzola, Mauro

AU - Buzi, Fabio

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