Age-dependent changes in B lymphocyte development in man and mouse

Paolo Ghia, Fritz Melchers, Antonius G. Rolink

Research output: Contribution to journalArticlepeer-review


In recent years, detailed analyses of B cell development in both humans and mice have revealed similar subsets of precursors along the same pathway of differentiation. From these studies it also became clear that both species undergo age related changes in this B lymphocyte development program. In this review we summarize these findings and discuss, potential mechanisms underlying these age related changes, and possible causative correlations between these changes and age related B cell abnormalities. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalExperimental Gerontology
Issue number2
Publication statusPublished - Mar 2000

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)


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