Age-dependent changes in the mechanisms regulating dopamine uptake in the central nervous system

C. Missale, S. Govoni, G. Pasinetti, C. Assini, P. F. Spano, F. Battaini, M. Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

Na+-dependent binding of 3H-Cocaine is located on dopaminergic terminals and is related to the dopamine uptake system. Studies on senescent rats indicate a decrease in 3H-Cocaine binding density in the striatum. In the same tissue an increase in the Km for dopamine uptake is observed. These changes might be relevant in the age-dependent alterations in dopaminergic function.

Original languageEnglish
Pages (from-to)136-139
Number of pages4
JournalJournals of Gerontology
Volume41
Issue number2
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Ageing

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