Age-dependent decrease of beta-adrenoceptor density in the submandibular glands of mice and its modulation by the thymus

Patrizia Fattoretti, Claudio Viticchi, Lucio Piantanelli

Research output: Contribution to journalArticlepeer-review

Abstract

Beta-adrenergic receptors were characterized in submandibular glands of ageing mice and old mice grafted with a neonatal thymus. No statistically significant changes of receptor affinity were found in the animal models investigated. On the contrary, receptor density showed a progressive decrease with advancing age. The age-related decrease has been found partially corrected in thymus-grafted old animals, which show a statistically significant recovery of receptor density when compared to their untreated littermates. Receptor modulation can be responsible for the age-related impairment and the thymus-dependent correction of beta-adrenergic responsiveness of submandibular glands previously observed in vivo. Hormonal balance and thyroid hormones, in particular, are suggested as being involved in the age- and thymus-dependent regulation of receptor density. In the accompanying Appendix, we describe the mathematical method used to calculate both specific and nonspecific binding from total binding data.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalArchives of Gerontology and Geriatrics
Volume1
Issue number3
DOIs
Publication statusPublished - 1982

Keywords

  • ageing
  • beta-adrenoreceptors
  • submandibular glands
  • thymus

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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