Age-dependent impairment of functional helper T cell responses to immunodominant epitopes of Toxoplasma gondii antigens in congenitally infected individuals

Silvia Guglietta, Elisa Beghetto, Andrea Spadoni, Wilma Buffolano, Paola Del Porto, Nicola Gargano

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Human infection with Toxoplasma gondii is generally asymptomatic in immunocompetent adults while it causes significant morbidity in congenitally infected children. Cell mediated immunity plays the main role in host resistance to T. gondii infection and a Th1 cytokine profile is necessary for protection and control of infection. The present work focused on comparing the helper T cell response to the GRA1 antigen of the parasite between children with congenital toxoplasmosis and healthy adults with acquired infection. We demonstrated that in young children with congenital infection the specific T cell response to parasite antigens is impaired and that such hypo-responsiveness is restored during childhood. Also, we provided clear evidence that in individuals with congenital toxoplasmosis the acquisition of functional helper T cell responses is disease-unrelated and indistinguishable in terms of strength, epitope specificity, and cytokine profile from the corresponding responses in immunocompetent adults with asymptomatic acquired T. gondii infection.

Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalMicrobes and Infection
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 2007

Fingerprint

Immunodominant Epitopes
Toxoplasmosis
Toxoplasma
Helper-Inducer T-Lymphocytes
Congenital Toxoplasmosis
Antigens
Parasites
Cytokines
Infection Control
Infection
Cellular Immunity
Epitopes
Morbidity
T-Lymphocytes

Keywords

  • Cellular immunity
  • Congenital toxoplasmosis
  • Recombinant antigens
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

Cite this

Age-dependent impairment of functional helper T cell responses to immunodominant epitopes of Toxoplasma gondii antigens in congenitally infected individuals. / Guglietta, Silvia; Beghetto, Elisa; Spadoni, Andrea; Buffolano, Wilma; Del Porto, Paola; Gargano, Nicola.

In: Microbes and Infection, Vol. 9, No. 2, 02.2007, p. 127-133.

Research output: Contribution to journalArticle

Guglietta, Silvia ; Beghetto, Elisa ; Spadoni, Andrea ; Buffolano, Wilma ; Del Porto, Paola ; Gargano, Nicola. / Age-dependent impairment of functional helper T cell responses to immunodominant epitopes of Toxoplasma gondii antigens in congenitally infected individuals. In: Microbes and Infection. 2007 ; Vol. 9, No. 2. pp. 127-133.
@article{e183e21d691f48f1b25ad49ac00ee316,
title = "Age-dependent impairment of functional helper T cell responses to immunodominant epitopes of Toxoplasma gondii antigens in congenitally infected individuals",
abstract = "Human infection with Toxoplasma gondii is generally asymptomatic in immunocompetent adults while it causes significant morbidity in congenitally infected children. Cell mediated immunity plays the main role in host resistance to T. gondii infection and a Th1 cytokine profile is necessary for protection and control of infection. The present work focused on comparing the helper T cell response to the GRA1 antigen of the parasite between children with congenital toxoplasmosis and healthy adults with acquired infection. We demonstrated that in young children with congenital infection the specific T cell response to parasite antigens is impaired and that such hypo-responsiveness is restored during childhood. Also, we provided clear evidence that in individuals with congenital toxoplasmosis the acquisition of functional helper T cell responses is disease-unrelated and indistinguishable in terms of strength, epitope specificity, and cytokine profile from the corresponding responses in immunocompetent adults with asymptomatic acquired T. gondii infection.",
keywords = "Cellular immunity, Congenital toxoplasmosis, Recombinant antigens, Toxoplasma gondii",
author = "Silvia Guglietta and Elisa Beghetto and Andrea Spadoni and Wilma Buffolano and {Del Porto}, Paola and Nicola Gargano",
year = "2007",
month = "2",
doi = "10.1016/j.micinf.2006.10.017",
language = "English",
volume = "9",
pages = "127--133",
journal = "Microbes and Infection",
issn = "1286-4579",
publisher = "Elsevier Masson SAS",
number = "2",

}

TY - JOUR

T1 - Age-dependent impairment of functional helper T cell responses to immunodominant epitopes of Toxoplasma gondii antigens in congenitally infected individuals

AU - Guglietta, Silvia

AU - Beghetto, Elisa

AU - Spadoni, Andrea

AU - Buffolano, Wilma

AU - Del Porto, Paola

AU - Gargano, Nicola

PY - 2007/2

Y1 - 2007/2

N2 - Human infection with Toxoplasma gondii is generally asymptomatic in immunocompetent adults while it causes significant morbidity in congenitally infected children. Cell mediated immunity plays the main role in host resistance to T. gondii infection and a Th1 cytokine profile is necessary for protection and control of infection. The present work focused on comparing the helper T cell response to the GRA1 antigen of the parasite between children with congenital toxoplasmosis and healthy adults with acquired infection. We demonstrated that in young children with congenital infection the specific T cell response to parasite antigens is impaired and that such hypo-responsiveness is restored during childhood. Also, we provided clear evidence that in individuals with congenital toxoplasmosis the acquisition of functional helper T cell responses is disease-unrelated and indistinguishable in terms of strength, epitope specificity, and cytokine profile from the corresponding responses in immunocompetent adults with asymptomatic acquired T. gondii infection.

AB - Human infection with Toxoplasma gondii is generally asymptomatic in immunocompetent adults while it causes significant morbidity in congenitally infected children. Cell mediated immunity plays the main role in host resistance to T. gondii infection and a Th1 cytokine profile is necessary for protection and control of infection. The present work focused on comparing the helper T cell response to the GRA1 antigen of the parasite between children with congenital toxoplasmosis and healthy adults with acquired infection. We demonstrated that in young children with congenital infection the specific T cell response to parasite antigens is impaired and that such hypo-responsiveness is restored during childhood. Also, we provided clear evidence that in individuals with congenital toxoplasmosis the acquisition of functional helper T cell responses is disease-unrelated and indistinguishable in terms of strength, epitope specificity, and cytokine profile from the corresponding responses in immunocompetent adults with asymptomatic acquired T. gondii infection.

KW - Cellular immunity

KW - Congenital toxoplasmosis

KW - Recombinant antigens

KW - Toxoplasma gondii

UR - http://www.scopus.com/inward/record.url?scp=33846854870&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846854870&partnerID=8YFLogxK

U2 - 10.1016/j.micinf.2006.10.017

DO - 10.1016/j.micinf.2006.10.017

M3 - Article

VL - 9

SP - 127

EP - 133

JO - Microbes and Infection

JF - Microbes and Infection

SN - 1286-4579

IS - 2

ER -