Age-dependent loss of cholinergic neurones in basal ganglia of rats

Maria Concetta Altavista, Anna Rita Bentivoglio, Paola Crociani, Paola Rossi, Alberto Albanese

Research output: Contribution to journalArticle

Abstract

A morphometric study of the striatal complex has been performed in adult and aged rats, by means of Butcher's acetylcholinesterase (AChE) staining. The size of neostriatum, and the number of putatively cholinergic AChE-positive perikarya, are significantly reduced in two-year-old rats. Consequently, mean cell density is decreased in the striatal complex by 15.58%; age-dependent loss is more pronounced: (1) in the dorsal and lateral parts of neostriatum, which in adults have a higher neural density; and (2) in the ventromedial part, which in the aged becomes almost void of neurones. It is concluded that depletion of cholinergic perikarya is a specific feature of natural ageing, which affects diffusely the neostriatum, and particularly its ventromedial territories.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalBrain Research
Volume455
Issue number1
DOIs
Publication statusPublished - Jul 5 1988

Keywords

  • Acetylcholinesterase
  • Ageing
  • Morphology
  • Neostriatum

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Age-dependent loss of cholinergic neurones in basal ganglia of rats'. Together they form a unique fingerprint.

  • Cite this