Age-dependent neurologic manifestations of HIV infection in childhood

L. Angelini, F. Zibordi, F. Triulzi, P. Cinque, B. Giudici, R. Pinzani, A. Plebani

Research output: Contribution to journalArticle

Abstract

Although the neurologic complications of HIV-1 infection during the first two years of life have been defined, the neurologic features in older children are not so well described. The present report is focused on the age-dependent neurologic presentation of HIV-1 infection. Sixty-two vertically HIV-1 infected children underwent detailed serial evaluations: neurologic assessment, neuropsychological tests, neuroimaging studies, and cerebrospinal fluid analysis. Neurologic involvement was found in 30 patients (48.3%). This population was divided into two groups, exhibiting progressive (83.3%) or nonprogressive (16.6%) neurologic signs and symptoms. In the first group of patients, progressive encephalopathy was distinguished from spastic paraparesis, possibly due to spinal cord involvement. The second group, represented by long-term survivors, requires clinical monitoring due to the possible prognostic value of acquired but presently nonprogressive signs of brain involvement. In contrast with the stereotyped features of the early form of progressive encephalopathy, the late form showed a polymorphic picture, with age-dependent neurologic manifestations. Multifocal white matter alterations and cerebral calcifications (sometimes with delayed onset and progression) were the prominent imaging findings. A correlation between cerebrospinal fluid HIV RNA levels, suggestive of viral replication within the central nervous system, and progressive neurological disease were also found.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalNeurological Sciences
Volume21
Issue number3
DOIs
Publication statusPublished - Jun 2000

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Neurologic Manifestations
Nervous System
HIV Infections
HIV-1
Brain Diseases
Cerebrospinal Fluid
Spastic Paraparesis
Neuropsychological Tests
Neuroimaging
Survivors
Spinal Cord
Central Nervous System
HIV
RNA
Brain
Population

Keywords

  • Central nervous system
  • Children
  • Human immunodeficiency virus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Age-dependent neurologic manifestations of HIV infection in childhood. / Angelini, L.; Zibordi, F.; Triulzi, F.; Cinque, P.; Giudici, B.; Pinzani, R.; Plebani, A.

In: Neurological Sciences, Vol. 21, No. 3, 06.2000, p. 135-142.

Research output: Contribution to journalArticle

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