Age-dependent skewing of X chromosome inactivation appears delayed in centenarians' offspring. Is there a role for allelic imbalance in Healthy Aging and Longevity?

Davide Gentilini, Davide Castaldi, Daniela Mari, Daniela Monti, Claudio Franceschi, Anna Maria di Blasio, Giovanni Vitale

Research output: Contribution to journalArticle

Abstract

Recently, it has been proposed that age-related X chromosome inactivation (XCI) skewing can clinically result in late-onset X-linked disorders. This observation leads to hypothesize that age-related skewed XCI might also influence lifespan in women. To investigate this issue, we employed a new experimental model of longevity and healthy aging including 55 female centenarians, 40 of their offspring, 33 age-matched offspring of both non-long-lived parents and 41 young women. Peripheral blood DNA from 169 females was screened for heterozygosity at the HUMARA locus. We confirmed that skewing of XCI is an age-dependent phenomenon. However, skewed XCI was significantly less severe and frequent in centenarians' offspring [degree of skewing (DS)=0.16±0.02] compared to age-matched offspring of both non-long-lived parents (DS= 0.24±0.02) (P

Original languageEnglish
Pages (from-to)277-283
Number of pages7
JournalAging Cell
Volume11
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Centenarians
  • Genetics
  • Life span
  • Longevity
  • Longevity regulation
  • Molecular biology of aging

ASJC Scopus subject areas

  • Cell Biology
  • Ageing

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