Age, height, and sex on motor evoked potentials

Translational data from a large italian cohort in a clinical environment

Mariagiovanna Cantone, Giuseppe Lanza, Luisa Vinciguerra, Valentina Puglisi, Riccardo Ricceri, Francesco Fisicaro, Carla Vagli, Rita Bella, Raffaele Ferri, Giovanni Pennisi, Vincenzo Di Lazzaro, Manuela Pennisi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: Motor evoked potentials (MEPs) to transcranial magnetic stimulation (TMS) are known to be susceptible to several sources of variability. However, conflicting evidences on individual characteristics in relatively small sample sizes have been reported. We investigated the effect of age, height, and sex on MEPs of the motor cortex and spinal roots in a large cohort. Methods: A total of 587 subjects clinically and neuroradiologically intact were included. MEPs were recorded during mild tonic contraction through a circular coil applied over the “hot spot” of the first dorsal interosseous and tibialis anterior muscles (TAs), bilaterally. Central motor conduction time (CMCT) was estimated as the difference between MEP cortical latency and the peripheral motor conduction time (PMCT) by cervical or lumbar magnetic stimulation. Peak-to-peak MEP amplitude to cortical stimulation and right-to-left difference of each parameter were also measured. Results: After Bonferroni correction, general linear (multiple) regression analysis showed that both MEP cortical latency and PMCT at four limbs positively correlated with age and height. At lower limbs, an independent effect of sex on the same measures was also observed (with females showing smaller values than males). CMCT correlated with both age (negatively) and height (positively) when analyzed by a single regression; however, with a multiple regression analysis this significance disappeared, due to the correction for the multicollinearity within the dataset. Conclusion: Physical individual features need to be considered for a more accurate and meaningful MEPs interpretation. Both in clinical practice and in research setting, patients and controls should be matched for age, height, and sex.

Original languageEnglish
Article number185
JournalFrontiers in Human Neuroscience
Volume13
DOIs
Publication statusPublished - Feb 1 2019

Fingerprint

Motor Evoked Potentials
Regression Analysis
Transcranial Magnetic Stimulation
Spinal Nerve Roots
Motor Cortex
Sample Size
Lower Extremity
Linear Models
Extremities
Muscles
Research

Keywords

  • Central motor conduction time
  • Motor evoked potentials
  • Physical variables
  • Reference values
  • Transcranial magnetic stimulation
  • Translational neurophysiology

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Age, height, and sex on motor evoked potentials : Translational data from a large italian cohort in a clinical environment. / Cantone, Mariagiovanna; Lanza, Giuseppe; Vinciguerra, Luisa; Puglisi, Valentina; Ricceri, Riccardo; Fisicaro, Francesco; Vagli, Carla; Bella, Rita; Ferri, Raffaele; Pennisi, Giovanni; Di Lazzaro, Vincenzo; Pennisi, Manuela.

In: Frontiers in Human Neuroscience, Vol. 13, 185, 01.02.2019.

Research output: Contribution to journalArticle

Cantone, M, Lanza, G, Vinciguerra, L, Puglisi, V, Ricceri, R, Fisicaro, F, Vagli, C, Bella, R, Ferri, R, Pennisi, G, Di Lazzaro, V & Pennisi, M 2019, 'Age, height, and sex on motor evoked potentials: Translational data from a large italian cohort in a clinical environment', Frontiers in Human Neuroscience, vol. 13, 185. https://doi.org/10.3389/fnhum.2019.00185
Cantone, Mariagiovanna ; Lanza, Giuseppe ; Vinciguerra, Luisa ; Puglisi, Valentina ; Ricceri, Riccardo ; Fisicaro, Francesco ; Vagli, Carla ; Bella, Rita ; Ferri, Raffaele ; Pennisi, Giovanni ; Di Lazzaro, Vincenzo ; Pennisi, Manuela. / Age, height, and sex on motor evoked potentials : Translational data from a large italian cohort in a clinical environment. In: Frontiers in Human Neuroscience. 2019 ; Vol. 13.
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AU - Puglisi, Valentina

AU - Ricceri, Riccardo

AU - Fisicaro, Francesco

AU - Vagli, Carla

AU - Bella, Rita

AU - Ferri, Raffaele

AU - Pennisi, Giovanni

AU - Di Lazzaro, Vincenzo

AU - Pennisi, Manuela

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N2 - Introduction: Motor evoked potentials (MEPs) to transcranial magnetic stimulation (TMS) are known to be susceptible to several sources of variability. However, conflicting evidences on individual characteristics in relatively small sample sizes have been reported. We investigated the effect of age, height, and sex on MEPs of the motor cortex and spinal roots in a large cohort. Methods: A total of 587 subjects clinically and neuroradiologically intact were included. MEPs were recorded during mild tonic contraction through a circular coil applied over the “hot spot” of the first dorsal interosseous and tibialis anterior muscles (TAs), bilaterally. Central motor conduction time (CMCT) was estimated as the difference between MEP cortical latency and the peripheral motor conduction time (PMCT) by cervical or lumbar magnetic stimulation. Peak-to-peak MEP amplitude to cortical stimulation and right-to-left difference of each parameter were also measured. Results: After Bonferroni correction, general linear (multiple) regression analysis showed that both MEP cortical latency and PMCT at four limbs positively correlated with age and height. At lower limbs, an independent effect of sex on the same measures was also observed (with females showing smaller values than males). CMCT correlated with both age (negatively) and height (positively) when analyzed by a single regression; however, with a multiple regression analysis this significance disappeared, due to the correction for the multicollinearity within the dataset. Conclusion: Physical individual features need to be considered for a more accurate and meaningful MEPs interpretation. Both in clinical practice and in research setting, patients and controls should be matched for age, height, and sex.

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