Age-independency of AP site incision capacity in women

Ottavio Rossi, Fabio Carrozzino, Guido Frosina

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Women in the age range 40-59 years have a >4 fold higher risk to develop cancer as compared to women in the age range birth-39 years. This age-related increase in cancer incidence might be partially linked to reduced efficiency of the DNA repair machinery. We have investigated the abasic (AP) site incision capacity of peripheral blood lymphocytes (PBL) from 23 women in the age range 27-57 years. The AP sites incision capacity was determined in relation to protein or DNA content of PBL extracts. In either case, no significant correlation was found between AP sites incision capacity and age, thus suggesting that no decline occurs in the age range investigated.

Original languageEnglish
Pages (from-to)256-259
Number of pages4
JournalEnvironmental and Molecular Mutagenesis
Volume34
Issue number4
DOIs
Publication statusPublished - 1999

Fingerprint

Lymphocytes
Blood
DNA
Machinery
Repair
DNA Repair
cancer
Neoplasms
blood
Parturition
Proteins
Incidence
machinery
repair
woman
fold
protein

Keywords

  • Abasic sites
  • Aging
  • DNA repair
  • In vitro assay
  • Peripheral blood lymphocytes

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Genetics
  • Genetics(clinical)
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Age-independency of AP site incision capacity in women. / Rossi, Ottavio; Carrozzino, Fabio; Frosina, Guido.

In: Environmental and Molecular Mutagenesis, Vol. 34, No. 4, 1999, p. 256-259.

Research output: Contribution to journalArticle

Rossi, Ottavio ; Carrozzino, Fabio ; Frosina, Guido. / Age-independency of AP site incision capacity in women. In: Environmental and Molecular Mutagenesis. 1999 ; Vol. 34, No. 4. pp. 256-259.
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