Age influences the skin reaction pattern to mechanical stress and its repair level through skin care products

Christos C. Zouboulis, Rana Elewa, Monica Ottaviani, Joachim Fluhr, Mauro Picardo, Armand Bernois, Catherine Heusèle, Emanuela Camera

Research output: Contribution to journalArticlepeer-review


Skin aging is associated with alterations of surface texture, sebum composition and immune response. Mechanical stress induces repair mechanisms, which may be dependent on the age and quality of the skin. The response to mechanical stress in young and aged individuals, their subjective opinion and the objective effectiveness of skin care products were evaluated by biophysical skin quality parameters (stratum corneum hydration, transepidermal water loss, skin pH, pigmentation and erythema) at baseline, 1, 6, 24. h and 7. days at the forearms of 2 groups of healthy volunteers, younger than 35 years (n = 11) and older than 60 years (n = 13). In addition, casual surface lipid composition was studied under the same conditions at the baseline and day 7 after mechanical stress induction. Evaluations were also performed in stressed skin areas treated daily with skin care products and the subjective opinion of the volunteers was additionally documented. The tested groups exhibited age-associated baseline skin functions as well as casual surface lipid composition and different reaction patterns to mechanical stress. Skin care was more effective in normalizing skin reaction to stress in the young than in the aged group. The subjective volunteer opinion correlated with the objective measurements.

Original languageEnglish
Number of pages8
JournalMechanisms of Ageing and Development
Publication statusPublished - Nov 2017


  • Aging skin
  • Biophysical assessment
  • Casual skin lipids
  • Skin care
  • Skin care products
  • Stress response

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology


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