Age of onset of myocardial infarction: Is promoter polymorphism of the RAGE gene implicated?

Chiara Boiocchi, Sara Bozzini, Maria Paola Buzzi, Sandra Schirinzi, Michele Zorzetto, Gabriele Pelissero, Mariaclara Cuccia, Colomba Falcone

Research output: Contribution to journalArticlepeer-review

Abstract

Receptor for advanced glycation endproducts (RAGE) is a cell-surface molecule member of the immunoglobulin superfamily and engages differing ligands relevant to distinct processes. A growing body of evidence has suggested that RAGE may promote vascular inflammation through several mechanisms. The objective of this study was to identify the possible relationship between the -374 T/A polymorphism of the RAGE gene, myocardial infarction (MI), and its age of onset. A total of 691 MI patients and 234 matched controls were investigated. In this study, the frequency of the A allele and AA genotype of the -374 T/A promoter polymorphism is significantly lower in patients with MI respect to the control group (p

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalRejuvenation Research
Volume14
Issue number1
DOIs
Publication statusPublished - Feb 1 2011

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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