Age of parents and risk of gestational trophoblastic disease

C. la Vecchia, F. Parazzini, A. Decarli, S. Franceschi, M. Fasoli, G. Favalli, E. Negri, S. Pampallona

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The relationship of gestational trophoblastic disease (GTD) to parental age was evaluated in a case-control study of 132 women with hydatidiform mole (108) or choriocarcinoma (24) and 304 control subjects hospitalized for normal deliveries. Cases and controls were recruited in Lombardy (Northern Italy), and all were white and Italian. Compared to the risk of developing trophoblastic tumors in women 21-35 years old, the risk of developing trophoblastic tumors was elevated both in younger [≤20 yr old, relative risk (RR) = 1.4, with 95% confidence interval (CI) of 0.7-2.8] and in older subjects. RR being 1.2 (95% CI 0.7-2.8) and 5.2 (95% CI 2.2-12.3) for women 36-40 years old and over 40, respectively. The risk estimates for the last two categories were reduced to 0.7 (with 95% CI of 0.3-1.9) and 2.5 (with 95% CI of 0.7-8.9) when adjustment was made for paternal age by means of the Mantel-Haenszel procedure. Higher paternal age also was associated with GTD: Women whose husbands were 41-45 years old and over 45 had RR of 1.6 (with 95% CI = 0.7-3.7) and 4.9 (with 95% CI = 2.2-11.1), respectively, compared to women married to men less than 40 years old. These risk estimates were practically unchanged when adjustment was made for the woman's age. Examination of the effects of parental and maternal ages suggests that the highest risk estimate was observed when both parents were older. The findings of the present study were consistent with increased risk in the youngest maternal age group and confirm that older maternal age is associated with increased risk of GTD. Furthermore, showing a strong, independent effect of paternal age, they give epidemiologic support to the cytogenetic evidence of an androgenetic role in the origin of GTD.

Original languageEnglish
Pages (from-to)639-642
Number of pages4
JournalJournal of the National Cancer Institute
Volume73
Issue number3
Publication statusPublished - 1984

Fingerprint

Gestational Trophoblastic Disease
Parents
Confidence Intervals
Paternal Age
Maternal Age
Trophoblastic Neoplasms
Social Adjustment
Hydatidiform Mole
Choriocarcinoma
Spouses
Cytogenetics
Italy
Case-Control Studies
Age Groups

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

la Vecchia, C., Parazzini, F., Decarli, A., Franceschi, S., Fasoli, M., Favalli, G., ... Pampallona, S. (1984). Age of parents and risk of gestational trophoblastic disease. Journal of the National Cancer Institute, 73(3), 639-642.

Age of parents and risk of gestational trophoblastic disease. / la Vecchia, C.; Parazzini, F.; Decarli, A.; Franceschi, S.; Fasoli, M.; Favalli, G.; Negri, E.; Pampallona, S.

In: Journal of the National Cancer Institute, Vol. 73, No. 3, 1984, p. 639-642.

Research output: Contribution to journalArticle

la Vecchia, C, Parazzini, F, Decarli, A, Franceschi, S, Fasoli, M, Favalli, G, Negri, E & Pampallona, S 1984, 'Age of parents and risk of gestational trophoblastic disease', Journal of the National Cancer Institute, vol. 73, no. 3, pp. 639-642.
la Vecchia C, Parazzini F, Decarli A, Franceschi S, Fasoli M, Favalli G et al. Age of parents and risk of gestational trophoblastic disease. Journal of the National Cancer Institute. 1984;73(3):639-642.
la Vecchia, C. ; Parazzini, F. ; Decarli, A. ; Franceschi, S. ; Fasoli, M. ; Favalli, G. ; Negri, E. ; Pampallona, S. / Age of parents and risk of gestational trophoblastic disease. In: Journal of the National Cancer Institute. 1984 ; Vol. 73, No. 3. pp. 639-642.
@article{2158b64650be42848c9113cfe619c8b5,
title = "Age of parents and risk of gestational trophoblastic disease",
abstract = "The relationship of gestational trophoblastic disease (GTD) to parental age was evaluated in a case-control study of 132 women with hydatidiform mole (108) or choriocarcinoma (24) and 304 control subjects hospitalized for normal deliveries. Cases and controls were recruited in Lombardy (Northern Italy), and all were white and Italian. Compared to the risk of developing trophoblastic tumors in women 21-35 years old, the risk of developing trophoblastic tumors was elevated both in younger [≤20 yr old, relative risk (RR) = 1.4, with 95{\%} confidence interval (CI) of 0.7-2.8] and in older subjects. RR being 1.2 (95{\%} CI 0.7-2.8) and 5.2 (95{\%} CI 2.2-12.3) for women 36-40 years old and over 40, respectively. The risk estimates for the last two categories were reduced to 0.7 (with 95{\%} CI of 0.3-1.9) and 2.5 (with 95{\%} CI of 0.7-8.9) when adjustment was made for paternal age by means of the Mantel-Haenszel procedure. Higher paternal age also was associated with GTD: Women whose husbands were 41-45 years old and over 45 had RR of 1.6 (with 95{\%} CI = 0.7-3.7) and 4.9 (with 95{\%} CI = 2.2-11.1), respectively, compared to women married to men less than 40 years old. These risk estimates were practically unchanged when adjustment was made for the woman's age. Examination of the effects of parental and maternal ages suggests that the highest risk estimate was observed when both parents were older. The findings of the present study were consistent with increased risk in the youngest maternal age group and confirm that older maternal age is associated with increased risk of GTD. Furthermore, showing a strong, independent effect of paternal age, they give epidemiologic support to the cytogenetic evidence of an androgenetic role in the origin of GTD.",
author = "{la Vecchia}, C. and F. Parazzini and A. Decarli and S. Franceschi and M. Fasoli and G. Favalli and E. Negri and S. Pampallona",
year = "1984",
language = "English",
volume = "73",
pages = "639--642",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Age of parents and risk of gestational trophoblastic disease

AU - la Vecchia, C.

AU - Parazzini, F.

AU - Decarli, A.

AU - Franceschi, S.

AU - Fasoli, M.

AU - Favalli, G.

AU - Negri, E.

AU - Pampallona, S.

PY - 1984

Y1 - 1984

N2 - The relationship of gestational trophoblastic disease (GTD) to parental age was evaluated in a case-control study of 132 women with hydatidiform mole (108) or choriocarcinoma (24) and 304 control subjects hospitalized for normal deliveries. Cases and controls were recruited in Lombardy (Northern Italy), and all were white and Italian. Compared to the risk of developing trophoblastic tumors in women 21-35 years old, the risk of developing trophoblastic tumors was elevated both in younger [≤20 yr old, relative risk (RR) = 1.4, with 95% confidence interval (CI) of 0.7-2.8] and in older subjects. RR being 1.2 (95% CI 0.7-2.8) and 5.2 (95% CI 2.2-12.3) for women 36-40 years old and over 40, respectively. The risk estimates for the last two categories were reduced to 0.7 (with 95% CI of 0.3-1.9) and 2.5 (with 95% CI of 0.7-8.9) when adjustment was made for paternal age by means of the Mantel-Haenszel procedure. Higher paternal age also was associated with GTD: Women whose husbands were 41-45 years old and over 45 had RR of 1.6 (with 95% CI = 0.7-3.7) and 4.9 (with 95% CI = 2.2-11.1), respectively, compared to women married to men less than 40 years old. These risk estimates were practically unchanged when adjustment was made for the woman's age. Examination of the effects of parental and maternal ages suggests that the highest risk estimate was observed when both parents were older. The findings of the present study were consistent with increased risk in the youngest maternal age group and confirm that older maternal age is associated with increased risk of GTD. Furthermore, showing a strong, independent effect of paternal age, they give epidemiologic support to the cytogenetic evidence of an androgenetic role in the origin of GTD.

AB - The relationship of gestational trophoblastic disease (GTD) to parental age was evaluated in a case-control study of 132 women with hydatidiform mole (108) or choriocarcinoma (24) and 304 control subjects hospitalized for normal deliveries. Cases and controls were recruited in Lombardy (Northern Italy), and all were white and Italian. Compared to the risk of developing trophoblastic tumors in women 21-35 years old, the risk of developing trophoblastic tumors was elevated both in younger [≤20 yr old, relative risk (RR) = 1.4, with 95% confidence interval (CI) of 0.7-2.8] and in older subjects. RR being 1.2 (95% CI 0.7-2.8) and 5.2 (95% CI 2.2-12.3) for women 36-40 years old and over 40, respectively. The risk estimates for the last two categories were reduced to 0.7 (with 95% CI of 0.3-1.9) and 2.5 (with 95% CI of 0.7-8.9) when adjustment was made for paternal age by means of the Mantel-Haenszel procedure. Higher paternal age also was associated with GTD: Women whose husbands were 41-45 years old and over 45 had RR of 1.6 (with 95% CI = 0.7-3.7) and 4.9 (with 95% CI = 2.2-11.1), respectively, compared to women married to men less than 40 years old. These risk estimates were practically unchanged when adjustment was made for the woman's age. Examination of the effects of parental and maternal ages suggests that the highest risk estimate was observed when both parents were older. The findings of the present study were consistent with increased risk in the youngest maternal age group and confirm that older maternal age is associated with increased risk of GTD. Furthermore, showing a strong, independent effect of paternal age, they give epidemiologic support to the cytogenetic evidence of an androgenetic role in the origin of GTD.

UR - http://www.scopus.com/inward/record.url?scp=0021145848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021145848&partnerID=8YFLogxK

M3 - Article

C2 - 6088880

AN - SCOPUS:0021145848

VL - 73

SP - 639

EP - 642

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 3

ER -