Age-related activation of the tyrosine kinase receptor protooncogenes RET and NTRK1 in papillary thyroid carcinoma

Italia Bongarzone, Laura Fugazzola, Paolo Vigneri, Luigi Mariani, Piera Mondellini, Furio Pacini, Fulvio Basolo, Aldo Pinchera, Silvana Pilotti, Marco Alessandro Pierotti

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Abstract

Oncogenic rearrangements of RET and NTRK1 proto-oncogenes are frequently detected in papillary thyroid carcinomas. Several studies have shown an association between ionizing radiation and development of this tumor type. In addition in vitro irradiation of tumor cell lines induced rearrangements of RET similar to those observed in human papillary, thyroid carcinomas. These two observations could be related to the reported increased incidence of papillary thyroid carcinomas in children living in contaminated areas around Chernobyl, given that it has been demonstrated that about 60% of them presents a RET oncogenic activation. However, this high frequency of RET positivity in radiation exposed children does not rule out the possibility that age could also play a role in the development of RET positive tumors. To assess this possibility we looked for a relationship between the presence of RET and NTRK1 oncogenic rearrangements nod age at surgery in a sample of 92 consecutive patients. Our results show that, in papillary thyroid carcinoma, the frequency of RET and NTRK1 activation is significantly higher in the group of patients aged 4-30 years, thas supporting the concept that age could be contributing to this thyroid specific carcinogenic process.

Original languageEnglish
Pages (from-to)2006-2009
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume81
Issue number5
DOIs
Publication statusPublished - 1996

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Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases
Tumors
Chemical activation
Ionizing radiation
Surgery
Proto-Oncogenes
Ionizing Radiation
Tumor Cell Line
Cells
Association reactions
Irradiation
Radiation
Neoplasms
Thyroid Gland
Papillary Thyroid cancer
Incidence

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Age-related activation of the tyrosine kinase receptor protooncogenes RET and NTRK1 in papillary thyroid carcinoma. / Bongarzone, Italia; Fugazzola, Laura; Vigneri, Paolo; Mariani, Luigi; Mondellini, Piera; Pacini, Furio; Basolo, Fulvio; Pinchera, Aldo; Pilotti, Silvana; Pierotti, Marco Alessandro.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 81, No. 5, 1996, p. 2006-2009.

Research output: Contribution to journalArticle

Bongarzone, Italia ; Fugazzola, Laura ; Vigneri, Paolo ; Mariani, Luigi ; Mondellini, Piera ; Pacini, Furio ; Basolo, Fulvio ; Pinchera, Aldo ; Pilotti, Silvana ; Pierotti, Marco Alessandro. / Age-related activation of the tyrosine kinase receptor protooncogenes RET and NTRK1 in papillary thyroid carcinoma. In: Journal of Clinical Endocrinology and Metabolism. 1996 ; Vol. 81, No. 5. pp. 2006-2009.
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AU - Mariani, Luigi

AU - Mondellini, Piera

AU - Pacini, Furio

AU - Basolo, Fulvio

AU - Pinchera, Aldo

AU - Pilotti, Silvana

AU - Pierotti, Marco Alessandro

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AB - Oncogenic rearrangements of RET and NTRK1 proto-oncogenes are frequently detected in papillary thyroid carcinomas. Several studies have shown an association between ionizing radiation and development of this tumor type. In addition in vitro irradiation of tumor cell lines induced rearrangements of RET similar to those observed in human papillary, thyroid carcinomas. These two observations could be related to the reported increased incidence of papillary thyroid carcinomas in children living in contaminated areas around Chernobyl, given that it has been demonstrated that about 60% of them presents a RET oncogenic activation. However, this high frequency of RET positivity in radiation exposed children does not rule out the possibility that age could also play a role in the development of RET positive tumors. To assess this possibility we looked for a relationship between the presence of RET and NTRK1 oncogenic rearrangements nod age at surgery in a sample of 92 consecutive patients. Our results show that, in papillary thyroid carcinoma, the frequency of RET and NTRK1 activation is significantly higher in the group of patients aged 4-30 years, thas supporting the concept that age could be contributing to this thyroid specific carcinogenic process.

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