Alterazione del signaling dei recettori beta-adrenergici cardiaci correlate all'invecchiamento ed allo scompenso cardiaco: Nuove prospettive terapeutiche per il trattamento delle malattie cardiovascolari

Translated title of the contribution: Age-related and heart failure-related beta-adrenergic receptor dysfunction: New therapeutic strategies for the treatment of cardiovascular diseases

G. D. Femminella, R. Formisano, L. Petraglia, D. Liccardo, K. Komici, A. Cannavo, C. De Lucia, V. Parisi, E. Allocca, C. Zincarelli, N. Ferrara, Dario Leosco

Research output: Contribution to journalArticle

Abstract

Heart failure is a leading cause of morbidity and mortality in the elderly. During the initial phase of the disease, compensatory mechanisms to stimulate cardiac contractility are activated by catecholamines (neuro-hormones) through a hyperstimulation of B-adrenergic receptors. However, prolonged hyperstimulation becomes detrimental in heart failure leading to disease progression. G-protein coupled receptors are a superfamily of plasma membrane receptors which represent an important target of heart failure drug therapy. Despite the introduction of successful drug classes, such as beta-adrenergic receptor blockers and angiotensin-converting enzyme inhibitors, heart failure still poses an enormous challenge and there is an urgent need to develop innovative treatments counteracting mechanisms involved in heart failure, acting at the G protein coupled receptor level. In this review, we will focus on β1- and β2-adrenergic receptor function and the role of the G protein coupled receptor kinase 2, GRK2, in heart failure management in the elderly. In particular, we will discuss how GRK2 inhibition by βARKct or potential pharmacological inhibitors might represent a new therapeutic target in heart failure.

Translated title of the contributionAge-related and heart failure-related beta-adrenergic receptor dysfunction: New therapeutic strategies for the treatment of cardiovascular diseases
Original languageItalian
Pages (from-to)241-247
Number of pages7
JournalGiornale di Gerontologia
Volume61
Issue number5
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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    Femminella, G. D., Formisano, R., Petraglia, L., Liccardo, D., Komici, K., Cannavo, A., De Lucia, C., Parisi, V., Allocca, E., Zincarelli, C., Ferrara, N., & Leosco, D. (2013). Alterazione del signaling dei recettori beta-adrenergici cardiaci correlate all'invecchiamento ed allo scompenso cardiaco: Nuove prospettive terapeutiche per il trattamento delle malattie cardiovascolari. Giornale di Gerontologia, 61(5), 241-247.