Age-related antihypertensive and haemodynamic effects of verapamil SR: Clinical results and effects on atrial natriuretic peptide

R. Antonicelli, P. F. Tomassini, P. Galletti, C. Gambini, M. Marini, L. Amadio, E. Paciaroni

Research output: Contribution to journalArticle

Abstract

The antihypertensive effect of the calcium-antagonist verapamil was investigated in two groups of patients, adult hypertensives (AH, <65 years of age) and elderly hypertensives (EH, > 65 years of age), who were treated with 240 mg p. o. sustained-release (SR) verapamil for 4 months. Arterial blood pressure was significantly reduced in both groups: the responders' rate was 65% in the AH group and 82% in the EG group. The heart rate was slightly but not significantly reduced. An improvement in cardiac haemodynamics was observed [cardiac index (CI), from 3.00 ± 0.51 to 3.25 ± 0.83 ml min-1 m-2 in AH and from 2.35 ± 1.08 to 3.04 ± 0.86 ml min-1 m-2 in EG]. We also evaluated the plasma concentrations of atrial natriuretic peptide (ANP) before and after treatment; ANP levels increased significantly only in the EH group. No serious side effects occurred. In conclusion, verapamil SR provided effective and well-tolerated antihypertensive treatment in both adult and elderly patients.

Original languageEnglish
JournalEuropean Journal of Clinical Pharmacology
Volume39
Issue number1
DOIs
Publication statusPublished - Oct 1990

Keywords

  • atrial natriuretic peptide
  • clinical trial
  • elderly
  • hypertension
  • verapamil haemodynamics

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)
  • Pharmacology

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