Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease

Pavel Belov, Christopher Magnano, Jacqueline Krawiecki, Jesper Hagemeier, Niels Bergsland, Clive Beggs, Robert Zivadinov

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: To assess the relationship between cross-sectional area of internal jugular veins and brain volumes in healthy individuals without neurologic disease. Methods: A total of 193 healthy individuals without neurologic disease (63 male and 130 female; age > 20 to < 70 years) received magnetic resonance venography and structural brain magnetic resonance imaging at 3T. The internal jugular vein cross-sectional area was assessed at C2–C3, C4, C5–C6, and C7–T1. Normalized whole brain volume was assessed. Partial correlation analyses were used to determine associations. Results: There was an inverse relationship between normalized whole brain volume and total internal jugular vein cross-sectional area (C7–T1: males r = −0.346, p = 0.029; females r = −0.301, p = 0.002). After age adjustment, association of normalized whole brain volume and normalized gray matter volume with internal jugular vein cross-sectional area became positive in males (normalized whole brain volume and right internal jugular vein cross-sectional area (C2–C3) changed from r = −0.163 to r = 0.384, p = 0.002), but not in the females. Conclusion: Sex differences exist in the relationship between brain volume and internal jugular vein cross-sectional area in healthy individuals without neurologic disease.

Original languageEnglish
Pages (from-to)125-134
Number of pages10
JournalPhlebology
Volume32
Issue number2
Early online dateJul 9 2016
DOIs
Publication statusPublished - Mar 1 2017

Fingerprint

Jugular Veins
Nervous System Diseases
Atrophy
Brain
Phlebography
Sex Characteristics
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging

Keywords

  • aging
  • brain atrophy
  • Healthy individuals without neurologic disease
  • internal jugular veins
  • magnetic resonance imaging
  • magnetic resonance venography
  • sex

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease. / Belov, Pavel; Magnano, Christopher; Krawiecki, Jacqueline; Hagemeier, Jesper; Bergsland, Niels; Beggs, Clive; Zivadinov, Robert.

In: Phlebology, Vol. 32, No. 2, 01.03.2017, p. 125-134.

Research output: Contribution to journalArticle

Belov, Pavel ; Magnano, Christopher ; Krawiecki, Jacqueline ; Hagemeier, Jesper ; Bergsland, Niels ; Beggs, Clive ; Zivadinov, Robert. / Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease. In: Phlebology. 2017 ; Vol. 32, No. 2. pp. 125-134.
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