Age-related changes in periodic leg movements during sleep in patients with restless legs syndrome

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Abstract

Objective: The aim of this study was to evaluate and statistically describe the age-related changes in leg movements (LMs) during sleep in a large group of subjects with restless legs syndrome (RLS). Subjects and methods: One hundred eight untreated patients affected by idiopathic RLS were included in this study (mean age 52.0 years, min 7.5, max 83.2 years). The time structure of their polysomnographically recorded LMs was analyzed using an approach particularly appropriate for assessing their quantity, periodicity, and distribution during the night. Results: Periodic LMs during sleep (PLMS) increased in number gradually in the age groups. Their typical interval was approximately 24-28 s before the age of 55 years but at approximately 14-16 s after the age of 65 years. PLMS index reached a plateau at 15-25 years of age and remained stable up to 65 years; after this age, it showed an important increase. Periodicity index (PI) increased progressively up to the age of 35 years and then remained stable up to the age of 85 years. No correlation was found between PLMS index and PI. The number of PLMS per hour of sleep declined through the night in subjects aged 15-75 years; after this age, PLMS tended to be equally distributed across the entire night. Conclusions: The use of three main parameters derived from the analysis of leg motor activity during sleep in RLS patients (PLMS index, PI and PLMS time distribution) is capable of providing us with important information about the age-related changes of PLMS in this condition, which can be used in the evaluation of the sleep motor patterns in these subjects.

Original languageEnglish
Pages (from-to)790-798
Number of pages9
JournalSleep Medicine
Volume9
Issue number7
DOIs
Publication statusPublished - Oct 2008

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Restless Legs Syndrome
Leg
Sleep
Periodicity
Motor Activity

Keywords

  • Age
  • Periodic leg movements
  • Periodicity index
  • PLM index
  • Restless legs syndrome
  • Time distribution

ASJC Scopus subject areas

  • Dentistry(all)
  • Ophthalmology
  • Pulmonary and Respiratory Medicine
  • Neurology

Cite this

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title = "Age-related changes in periodic leg movements during sleep in patients with restless legs syndrome",
abstract = "Objective: The aim of this study was to evaluate and statistically describe the age-related changes in leg movements (LMs) during sleep in a large group of subjects with restless legs syndrome (RLS). Subjects and methods: One hundred eight untreated patients affected by idiopathic RLS were included in this study (mean age 52.0 years, min 7.5, max 83.2 years). The time structure of their polysomnographically recorded LMs was analyzed using an approach particularly appropriate for assessing their quantity, periodicity, and distribution during the night. Results: Periodic LMs during sleep (PLMS) increased in number gradually in the age groups. Their typical interval was approximately 24-28 s before the age of 55 years but at approximately 14-16 s after the age of 65 years. PLMS index reached a plateau at 15-25 years of age and remained stable up to 65 years; after this age, it showed an important increase. Periodicity index (PI) increased progressively up to the age of 35 years and then remained stable up to the age of 85 years. No correlation was found between PLMS index and PI. The number of PLMS per hour of sleep declined through the night in subjects aged 15-75 years; after this age, PLMS tended to be equally distributed across the entire night. Conclusions: The use of three main parameters derived from the analysis of leg motor activity during sleep in RLS patients (PLMS index, PI and PLMS time distribution) is capable of providing us with important information about the age-related changes of PLMS in this condition, which can be used in the evaluation of the sleep motor patterns in these subjects.",
keywords = "Age, Periodic leg movements, Periodicity index, PLM index, Restless legs syndrome, Time distribution",
author = "Raffaele Ferri and Mauro Manconi and Bartolo Lanuzza and Cosentino, {Filomena I I} and Oliviero Bruni and Luigi Ferini-Strambi and Marco Zucconi",
year = "2008",
month = "10",
doi = "10.1016/j.sleep.2007.08.020",
language = "English",
volume = "9",
pages = "790--798",
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T1 - Age-related changes in periodic leg movements during sleep in patients with restless legs syndrome

AU - Ferri, Raffaele

AU - Manconi, Mauro

AU - Lanuzza, Bartolo

AU - Cosentino, Filomena I I

AU - Bruni, Oliviero

AU - Ferini-Strambi, Luigi

AU - Zucconi, Marco

PY - 2008/10

Y1 - 2008/10

N2 - Objective: The aim of this study was to evaluate and statistically describe the age-related changes in leg movements (LMs) during sleep in a large group of subjects with restless legs syndrome (RLS). Subjects and methods: One hundred eight untreated patients affected by idiopathic RLS were included in this study (mean age 52.0 years, min 7.5, max 83.2 years). The time structure of their polysomnographically recorded LMs was analyzed using an approach particularly appropriate for assessing their quantity, periodicity, and distribution during the night. Results: Periodic LMs during sleep (PLMS) increased in number gradually in the age groups. Their typical interval was approximately 24-28 s before the age of 55 years but at approximately 14-16 s after the age of 65 years. PLMS index reached a plateau at 15-25 years of age and remained stable up to 65 years; after this age, it showed an important increase. Periodicity index (PI) increased progressively up to the age of 35 years and then remained stable up to the age of 85 years. No correlation was found between PLMS index and PI. The number of PLMS per hour of sleep declined through the night in subjects aged 15-75 years; after this age, PLMS tended to be equally distributed across the entire night. Conclusions: The use of three main parameters derived from the analysis of leg motor activity during sleep in RLS patients (PLMS index, PI and PLMS time distribution) is capable of providing us with important information about the age-related changes of PLMS in this condition, which can be used in the evaluation of the sleep motor patterns in these subjects.

AB - Objective: The aim of this study was to evaluate and statistically describe the age-related changes in leg movements (LMs) during sleep in a large group of subjects with restless legs syndrome (RLS). Subjects and methods: One hundred eight untreated patients affected by idiopathic RLS were included in this study (mean age 52.0 years, min 7.5, max 83.2 years). The time structure of their polysomnographically recorded LMs was analyzed using an approach particularly appropriate for assessing their quantity, periodicity, and distribution during the night. Results: Periodic LMs during sleep (PLMS) increased in number gradually in the age groups. Their typical interval was approximately 24-28 s before the age of 55 years but at approximately 14-16 s after the age of 65 years. PLMS index reached a plateau at 15-25 years of age and remained stable up to 65 years; after this age, it showed an important increase. Periodicity index (PI) increased progressively up to the age of 35 years and then remained stable up to the age of 85 years. No correlation was found between PLMS index and PI. The number of PLMS per hour of sleep declined through the night in subjects aged 15-75 years; after this age, PLMS tended to be equally distributed across the entire night. Conclusions: The use of three main parameters derived from the analysis of leg motor activity during sleep in RLS patients (PLMS index, PI and PLMS time distribution) is capable of providing us with important information about the age-related changes of PLMS in this condition, which can be used in the evaluation of the sleep motor patterns in these subjects.

KW - Age

KW - Periodic leg movements

KW - Periodicity index

KW - PLM index

KW - Restless legs syndrome

KW - Time distribution

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