Abstract
Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extracts indicates that the composition of the immunoreactive material is similar in the two age-groups investigated. At the thoracic level opiate receptor binding was also measured. Opiate receptor number is increased in the thoracic segments of the spinal cord from older rats. These age-related changes in immunoreactive Met-enkephalin content and opiate receptor number at spinal levels may contribute to determine an altered pain sensitivity during aging.
| Original language | English |
|---|---|
| Pages (from-to) | 160-162 |
| Number of pages | 3 |
| Journal | Brain Research |
| Volume | 262 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 28 1983 |
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Keywords
- aging
- Met-enkephalin
- opiate receptors
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Age related changes of enkephalin in rat spinal cord. / Missale, C.; Govoni, S.; Castelletti, L.; Spano, P. F.; Trabucchi, M.
In: Brain Research, Vol. 262, No. 1, 28.02.1983, p. 160-162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age related changes of enkephalin in rat spinal cord
AU - Missale, C.
AU - Govoni, S.
AU - Castelletti, L.
AU - Spano, P. F.
AU - Trabucchi, M.
PY - 1983/2/28
Y1 - 1983/2/28
N2 - Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extracts indicates that the composition of the immunoreactive material is similar in the two age-groups investigated. At the thoracic level opiate receptor binding was also measured. Opiate receptor number is increased in the thoracic segments of the spinal cord from older rats. These age-related changes in immunoreactive Met-enkephalin content and opiate receptor number at spinal levels may contribute to determine an altered pain sensitivity during aging.
AB - Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extracts indicates that the composition of the immunoreactive material is similar in the two age-groups investigated. At the thoracic level opiate receptor binding was also measured. Opiate receptor number is increased in the thoracic segments of the spinal cord from older rats. These age-related changes in immunoreactive Met-enkephalin content and opiate receptor number at spinal levels may contribute to determine an altered pain sensitivity during aging.
KW - aging
KW - Met-enkephalin
KW - opiate receptors
UR - http://www.scopus.com/inward/record.url?scp=0020671746&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020671746&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(83)90481-X
DO - 10.1016/0006-8993(83)90481-X
M3 - Article
VL - 262
SP - 160
EP - 162
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -