Age related changes of enkephalin in rat spinal cord

C. Missale; S. Govoni; L. Castelletti; P. F. Spano; M. Trabucchi

doi:10.1016/0006-8993(83)90481-X

Age related changes of enkephalin in rat spinal cord

C. Missale, S. Govoni, L. Castelletti, P. F. Spano, M. Trabucchi

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extracts indicates that the composition of the immunoreactive material is similar in the two age-groups investigated. At the thoracic level opiate receptor binding was also measured. Opiate receptor number is increased in the thoracic segments of the spinal cord from older rats. These age-related changes in immunoreactive Met-enkephalin content and opiate receptor number at spinal levels may contribute to determine an altered pain sensitivity during aging.

Original language	English
Pages (from-to)	160-162
Number of pages	3
Journal	Brain Research
Volume	262
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(83)90481-X
Publication status	Published - Feb 28 1983

Keywords

aging
Met-enkephalin
opiate receptors

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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AU - Missale, C.

AU - Govoni, S.

AU - Castelletti, L.

AU - Spano, P. F.

AU - Trabucchi, M.

PY - 1983/2/28

Y1 - 1983/2/28

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AB - Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extracts indicates that the composition of the immunoreactive material is similar in the two age-groups investigated. At the thoracic level opiate receptor binding was also measured. Opiate receptor number is increased in the thoracic segments of the spinal cord from older rats. These age-related changes in immunoreactive Met-enkephalin content and opiate receptor number at spinal levels may contribute to determine an altered pain sensitivity during aging.

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KW - Met-enkephalin

KW - opiate receptors

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Age related changes of enkephalin in rat spinal cord

Abstract

Keywords

ASJC Scopus subject areas

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