Age related changes of enkephalin in rat spinal cord

C. Missale, S. Govoni, L. Castelletti, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extracts indicates that the composition of the immunoreactive material is similar in the two age-groups investigated. At the thoracic level opiate receptor binding was also measured. Opiate receptor number is increased in the thoracic segments of the spinal cord from older rats. These age-related changes in immunoreactive Met-enkephalin content and opiate receptor number at spinal levels may contribute to determine an altered pain sensitivity during aging.

Original languageEnglish
Pages (from-to)160-162
Number of pages3
JournalBrain Research
Volume262
Issue number1
DOIs
Publication statusPublished - Feb 28 1983

Fingerprint

Enkephalins
Spinal Cord
Opioid Receptors
Thorax
Methionine Enkephalin
Chromatography
Age Groups
Gels
Pain

Keywords

  • aging
  • Met-enkephalin
  • opiate receptors

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Missale, C., Govoni, S., Castelletti, L., Spano, P. F., & Trabucchi, M. (1983). Age related changes of enkephalin in rat spinal cord. Brain Research, 262(1), 160-162. https://doi.org/10.1016/0006-8993(83)90481-X

Age related changes of enkephalin in rat spinal cord. / Missale, C.; Govoni, S.; Castelletti, L.; Spano, P. F.; Trabucchi, M.

In: Brain Research, Vol. 262, No. 1, 28.02.1983, p. 160-162.

Research output: Contribution to journalArticle

Missale, C, Govoni, S, Castelletti, L, Spano, PF & Trabucchi, M 1983, 'Age related changes of enkephalin in rat spinal cord', Brain Research, vol. 262, no. 1, pp. 160-162. https://doi.org/10.1016/0006-8993(83)90481-X
Missale C, Govoni S, Castelletti L, Spano PF, Trabucchi M. Age related changes of enkephalin in rat spinal cord. Brain Research. 1983 Feb 28;262(1):160-162. https://doi.org/10.1016/0006-8993(83)90481-X
Missale, C. ; Govoni, S. ; Castelletti, L. ; Spano, P. F. ; Trabucchi, M. / Age related changes of enkephalin in rat spinal cord. In: Brain Research. 1983 ; Vol. 262, No. 1. pp. 160-162.
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