Age related changes of enkephalin in rat spinal cord

C. Missale, S. Govoni, L. Castelletti, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticlepeer-review


Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extracts indicates that the composition of the immunoreactive material is similar in the two age-groups investigated. At the thoracic level opiate receptor binding was also measured. Opiate receptor number is increased in the thoracic segments of the spinal cord from older rats. These age-related changes in immunoreactive Met-enkephalin content and opiate receptor number at spinal levels may contribute to determine an altered pain sensitivity during aging.

Original languageEnglish
Pages (from-to)160-162
Number of pages3
JournalBrain Research
Issue number1
Publication statusPublished - Feb 28 1983


  • aging
  • Met-enkephalin
  • opiate receptors

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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