Age-related changes of GH-IGF1 axis function

Gianluigi Mazzoccoli, Michele Inglese, Mariangela Pia Dagostino, Ada Piepoli, Lucia Anna Muscarella, Valerio Pazienza, Roberto Tarquini, Francesco Giuliani

Research output: Contribution to journalArticlepeer-review


Background: There is a reduction in the GH-IGF1 axis activity with increasing age, but there is evidence that the pool of GH available for release is not diminished in elderly subjects. We investigated whether there are differences among healthy young-middle aged and old aged subjects in the 24 hour secretory profiles of GH and IGF1. Methods: The study was carried out on 15 healthy young-middle aged subjects (age range 36-55 years) and 15 healthy old aged subjects (age range 67-79 years). GH, IGF1, melatonin and cortisol serum levels were measuredonblood samplescollected every four hours for 24 hours. The fractional variation between single time point GH and IGF1 serum levels,mean photoperiod (06:00h-10:00h-14:00h) and scotoperiod (18:00h-22:00h-02:00h) values and the presence of circadian rhythmicity were evaluated. Results: A normal circadian rhythmicity was recognizable for GH, melatonin and cortisol secretion in young-middle aged and old aged subjects, MESOR of cortisol was higher in the elderly (P=0.002) and the acrophase of cortisol was advanced in the group of old aged subjects (P=0.03), whereas the amplitude of IGF1 was higher in the group of young-middle-aged subjects (P

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalBiomedicine and Aging Pathology
Issue number1
Publication statusPublished - Jan 2011


  • Aging
  • Circadian rhythm
  • Growth hormone
  • Insulin like growth factor-1

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Pathology and Forensic Medicine
  • Ageing

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