Abstract
Platelet receptors for PGI2 were investigated in eighteen healthy volunteers divided in two classes of age: nine were 18-40 years old and nine were 41-65 years old. PGI2 platelet receptors were found to decrease significantly with age; the young subjects had 106 ± 16 (mean ± SD) high affinity receptors/platelet and 3509 ± 529 low affinity receptors/platelet whereas the old subjects had 86 ± 14 high affinity receptors/platelet (P <0.02) and 2471 ± 640 low affinity receptors/platelet (P <0.005). The cumulated data from all the subjects yielded a significant negative correlation with age (r = -0.71, P <0.001 for the high affinity class and r = -0.65, P <0.01 for the low affinity class). The affinity of receptor sites for the ligand did not statistically change with aging (P <0.30 and P <0.90 respectively for high and low affinity receptors).
| Original language | English |
|---|---|
| Pages (from-to) | 204-208 |
| Number of pages | 5 |
| Journal | European Journal of Clinical Investigation |
| Volume | 15 |
| Issue number | 4 |
| Publication status | Published - 1985 |
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Age related changes of platelet prostacyclin receptors in humans. / Modesti, P. A.; Fortini, A.; Abbate, R.; Gensini, G. F.
In: European Journal of Clinical Investigation, Vol. 15, No. 4, 1985, p. 204-208.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age related changes of platelet prostacyclin receptors in humans
AU - Modesti, P. A.
AU - Fortini, A.
AU - Abbate, R.
AU - Gensini, G. F.
PY - 1985
Y1 - 1985
N2 - Platelet receptors for PGI2 were investigated in eighteen healthy volunteers divided in two classes of age: nine were 18-40 years old and nine were 41-65 years old. PGI2 platelet receptors were found to decrease significantly with age; the young subjects had 106 ± 16 (mean ± SD) high affinity receptors/platelet and 3509 ± 529 low affinity receptors/platelet whereas the old subjects had 86 ± 14 high affinity receptors/platelet (P <0.02) and 2471 ± 640 low affinity receptors/platelet (P <0.005). The cumulated data from all the subjects yielded a significant negative correlation with age (r = -0.71, P <0.001 for the high affinity class and r = -0.65, P <0.01 for the low affinity class). The affinity of receptor sites for the ligand did not statistically change with aging (P <0.30 and P <0.90 respectively for high and low affinity receptors).
AB - Platelet receptors for PGI2 were investigated in eighteen healthy volunteers divided in two classes of age: nine were 18-40 years old and nine were 41-65 years old. PGI2 platelet receptors were found to decrease significantly with age; the young subjects had 106 ± 16 (mean ± SD) high affinity receptors/platelet and 3509 ± 529 low affinity receptors/platelet whereas the old subjects had 86 ± 14 high affinity receptors/platelet (P <0.02) and 2471 ± 640 low affinity receptors/platelet (P <0.005). The cumulated data from all the subjects yielded a significant negative correlation with age (r = -0.71, P <0.001 for the high affinity class and r = -0.65, P <0.01 for the low affinity class). The affinity of receptor sites for the ligand did not statistically change with aging (P <0.30 and P <0.90 respectively for high and low affinity receptors).
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M3 - Article
C2 - 2995049
AN - SCOPUS:0022345924
VL - 15
SP - 204
EP - 208
JO - European Journal of Clinical Investigation
JF - European Journal of Clinical Investigation
SN - 0014-2972
IS - 4
ER -