Age related changes of platelet prostacyclin receptors in humans

P. A. Modesti, A. Fortini, R. Abbate, G. F. Gensini

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Platelet receptors for PGI2 were investigated in eighteen healthy volunteers divided in two classes of age: nine were 18-40 years old and nine were 41-65 years old. PGI2 platelet receptors were found to decrease significantly with age; the young subjects had 106 ± 16 (mean ± SD) high affinity receptors/platelet and 3509 ± 529 low affinity receptors/platelet whereas the old subjects had 86 ± 14 high affinity receptors/platelet (P <0.02) and 2471 ± 640 low affinity receptors/platelet (P <0.005). The cumulated data from all the subjects yielded a significant negative correlation with age (r = -0.71, P <0.001 for the high affinity class and r = -0.65, P <0.01 for the low affinity class). The affinity of receptor sites for the ligand did not statistically change with aging (P <0.30 and P <0.90 respectively for high and low affinity receptors).

Original languageEnglish
Pages (from-to)204-208
Number of pages5
JournalEuropean Journal of Clinical Investigation
Volume15
Issue number4
Publication statusPublished - 1985

Fingerprint

Epoprostenol Receptors
Platelets
Blood Platelets
Epoprostenol
human PTGIR protein
Healthy Volunteers
Aging of materials
Ligands

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Modesti, P. A., Fortini, A., Abbate, R., & Gensini, G. F. (1985). Age related changes of platelet prostacyclin receptors in humans. European Journal of Clinical Investigation, 15(4), 204-208.

Age related changes of platelet prostacyclin receptors in humans. / Modesti, P. A.; Fortini, A.; Abbate, R.; Gensini, G. F.

In: European Journal of Clinical Investigation, Vol. 15, No. 4, 1985, p. 204-208.

Research output: Contribution to journalArticle

Modesti, PA, Fortini, A, Abbate, R & Gensini, GF 1985, 'Age related changes of platelet prostacyclin receptors in humans', European Journal of Clinical Investigation, vol. 15, no. 4, pp. 204-208.
Modesti, P. A. ; Fortini, A. ; Abbate, R. ; Gensini, G. F. / Age related changes of platelet prostacyclin receptors in humans. In: European Journal of Clinical Investigation. 1985 ; Vol. 15, No. 4. pp. 204-208.
@article{a575e6e71eac4d0e8633493ccca9a2ac,
title = "Age related changes of platelet prostacyclin receptors in humans",
abstract = "Platelet receptors for PGI2 were investigated in eighteen healthy volunteers divided in two classes of age: nine were 18-40 years old and nine were 41-65 years old. PGI2 platelet receptors were found to decrease significantly with age; the young subjects had 106 ± 16 (mean ± SD) high affinity receptors/platelet and 3509 ± 529 low affinity receptors/platelet whereas the old subjects had 86 ± 14 high affinity receptors/platelet (P <0.02) and 2471 ± 640 low affinity receptors/platelet (P <0.005). The cumulated data from all the subjects yielded a significant negative correlation with age (r = -0.71, P <0.001 for the high affinity class and r = -0.65, P <0.01 for the low affinity class). The affinity of receptor sites for the ligand did not statistically change with aging (P <0.30 and P <0.90 respectively for high and low affinity receptors).",
author = "Modesti, {P. A.} and A. Fortini and R. Abbate and Gensini, {G. F.}",
year = "1985",
language = "English",
volume = "15",
pages = "204--208",
journal = "European Journal of Clinical Investigation",
issn = "0014-2972",
publisher = "Blackwell Publishing Ltd",
number = "4",

}

TY - JOUR

T1 - Age related changes of platelet prostacyclin receptors in humans

AU - Modesti, P. A.

AU - Fortini, A.

AU - Abbate, R.

AU - Gensini, G. F.

PY - 1985

Y1 - 1985

N2 - Platelet receptors for PGI2 were investigated in eighteen healthy volunteers divided in two classes of age: nine were 18-40 years old and nine were 41-65 years old. PGI2 platelet receptors were found to decrease significantly with age; the young subjects had 106 ± 16 (mean ± SD) high affinity receptors/platelet and 3509 ± 529 low affinity receptors/platelet whereas the old subjects had 86 ± 14 high affinity receptors/platelet (P <0.02) and 2471 ± 640 low affinity receptors/platelet (P <0.005). The cumulated data from all the subjects yielded a significant negative correlation with age (r = -0.71, P <0.001 for the high affinity class and r = -0.65, P <0.01 for the low affinity class). The affinity of receptor sites for the ligand did not statistically change with aging (P <0.30 and P <0.90 respectively for high and low affinity receptors).

AB - Platelet receptors for PGI2 were investigated in eighteen healthy volunteers divided in two classes of age: nine were 18-40 years old and nine were 41-65 years old. PGI2 platelet receptors were found to decrease significantly with age; the young subjects had 106 ± 16 (mean ± SD) high affinity receptors/platelet and 3509 ± 529 low affinity receptors/platelet whereas the old subjects had 86 ± 14 high affinity receptors/platelet (P <0.02) and 2471 ± 640 low affinity receptors/platelet (P <0.005). The cumulated data from all the subjects yielded a significant negative correlation with age (r = -0.71, P <0.001 for the high affinity class and r = -0.65, P <0.01 for the low affinity class). The affinity of receptor sites for the ligand did not statistically change with aging (P <0.30 and P <0.90 respectively for high and low affinity receptors).

UR - http://www.scopus.com/inward/record.url?scp=0022345924&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022345924&partnerID=8YFLogxK

M3 - Article

C2 - 2995049

AN - SCOPUS:0022345924

VL - 15

SP - 204

EP - 208

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

SN - 0014-2972

IS - 4

ER -