Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts

G. De Benedictis, L. Carotenuto, G. Carrieri, M. De Luca, E. Falcone, G. Rose, A. I. Yashin, M. Bonafè, C. Franceschi

Research output: Contribution to journalArticle

Abstract

The analysis of seven different age cohorts (697 individuals from 10 to 109 years old) revealed age-related changes in the 3'APOB-VNTR genotype pool. By recoding the 3'APOB-VNTR alleles into three size-classes (small, S, 26-34 repeats; medium, M, 35-39 repeats; large, L, 41-55 repeats), an age-related convex trajectory of the frequency of SS homozygotes was found. The frequency of SS in the genotype pool increased from the group aged 10-19 years (3.06 ± 1.74%) to that aged 40-49 years (8.51 ± 4.07%). Then it declined reaching the minimum value in centenarians (1.58 ± 0.90%). The observed trajectory is in agreement with that expected by assuming crossing of mortality curves relevant to subgroups of individuals having different genotypes.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalAnnals of Human Genetics
Volume62
Issue number2
DOIs
Publication statusPublished - Mar 1998

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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    De Benedictis, G., Carotenuto, L., Carrieri, G., De Luca, M., Falcone, E., Rose, G., Yashin, A. I., Bonafè, M., & Franceschi, C. (1998). Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts. Annals of Human Genetics, 62(2), 115-122. https://doi.org/10.1017/S0003480098006757