Age-related changes of the adrenal secretory pattern: Possible role in pathological brain aging

Ettore Ferrari, Daniela Casarotti, Barbara Muzzoni, Norma Albertelli, Luca Cravello, Marisa Fioravanti, Sebastiano Bruno Solerte, Flavia Magri

Research output: Contribution to journalArticlepeer-review


The biosynthetic dissociation of the adrenocortical secretion occurring with age may have a pathogenetic role in the pathophysiology of brain aging. We studied cortisol and DHEAS secretion in healthy old and young subjects, in senile dementia, in major depression of elderly subjects and in healthy centenarians. A clear age-related decline of DHEAS secretion was well evident in healthy centenarians, and a further decrease in DHEAS concentration was found in old depressed patients and moreover in the demented ones, by comparison with age-matched controls. The circadian profile of serum cortisol was clearly flattened in old subjects, due to the selective increase in the cortisol nocturnal levels, particularly evident in demented subjects; on the other hand, the morning serum cortisol levels were not significantly different among centenarians, young and old controls. The molar ratio between cortisol and DHEAS showed a significant age-related increase; the occurrence of senile dementia and of major depression played an additive role, by comparison to physiological aging. The qualitative and quantitative modifications of the adrenocortical secretion occurring with aging seem mainly dependent on age itself, but the occurrence of pathological conditions may amplify these changes. Since cortisol and DHEAS play opposite effects on the central nervous system, the evaluation of the ratio between cortisol and DHEAS seems to be a good marker of the neuroendocrine features in old subjects.

Original languageEnglish
Pages (from-to)294-300
Number of pages7
JournalBrain Research Reviews
Issue number1-3
Publication statusPublished - 2001


  • Centenarians
  • Cortisol
  • Pathological aging
  • Physiological aging

ASJC Scopus subject areas

  • Neuroscience(all)


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