Age-related cholinergic drug effects on analgesia in two inbred strains of mice

Sandro Fagioli, Donatella Consorti, Flaminia Pavone

Research output: Contribution to journalArticle

Abstract

The two inbred strains of mice C57BL/6 and DBA/2 are characterized by a different behavioral reactivity to cholinergic agents during development. The present experiment revealed that the strain-dependent differences in cholinergic-mediated analgesia during development disappeared during adult life. In fact, oxotremorine administration (0.0025 and 0.005 mg/kg) exerted the same analgesic effect in both strains at 6 months of age, in contrast with the finding of the lack of any effect of the drug in C57 mice at two months of age in comparison with DBA.

Original languageEnglish
Pages (from-to)150-153
Number of pages4
JournalBrain Research
Volume510
Issue number1
DOIs
Publication statusPublished - Feb 26 1990

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Keywords

  • Age
  • Analgesia
  • Mouse
  • Oxotremorine

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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