Age-related clinical severity at diagnosis in 1705 patients with ulcerative colitis: A study by GISC (Italian Colon-Rectum Study Group)

Gabriele Riegler, M. T. Tartaglione, R. Carratú, R. D'Incá, D. Valpiani, M. I. Russo, C. Papi, M. T. Fiorentini, M. Ingrosso, A. Andreoli, M. Vecchi, F. Morace, L. Caserta, A. Piscitelli, P. Esposito, R. Marmo, D. Cantarini, S. Gullini, M. C. Di Paolo, M. A. PelliR. Garcea, G. Novelli, C. Mansi, V. Annese, P. Usai, D. Assisi, G. Frieri, S. Pignatari, M. Astegiano, A. Pisani, R. Mangiarotti

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Clinical-endoscopic parameters of UC presentation were studied in 1705 out-patients, observed consecutively in 17 Italian gastroenterology centers (males 60.2%; average age at diagnosis 38.5 ± 16.4 years), and were subdivided arbitrarily into quartile age groups at diagnosis (0-25, 26-35, 36-50, >50). A significantly greater prevalence in males, increasing with age, was shown at diagnosis (P = 0.0002), which seems to correlate with the condition of being an ex-smoker, most frequently found in males. The greater frequency of exsmokers could also, in part, justify the second peak of incidence in old age. Greater colitis extent, greater clinical activity, and greater use of steroids as the first therapeutic step are shown to prevail among younger patients and among women (P = 0.02 and P = 0.019, respectively). The same is observed for symptoms mainly representing clinical severity such as diarrhea, fever, and weight loss (P = 0.004; P = 0.006; P = 0.009, respectively). This study confirms the UC risk factor represented by the condition of being an ex-smoker and shows a greater severity of illness on diagnosis in younger patients.

Original languageEnglish
Pages (from-to)462-465
Number of pages4
JournalDigestive Diseases and Sciences
Volume45
Issue number3
DOIs
Publication statusPublished - 2000

Fingerprint

Ulcerative Colitis
Rectum
Colon
Gastroenterology
Colitis
Weight Loss
Diarrhea
Fever
Outpatients
Age Groups
Steroids
Incidence
Therapeutics

Keywords

  • Clinical features
  • Elderly
  • Epidemiology
  • Natural history
  • Smoking habit
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Age-related clinical severity at diagnosis in 1705 patients with ulcerative colitis : A study by GISC (Italian Colon-Rectum Study Group). / Riegler, Gabriele; Tartaglione, M. T.; Carratú, R.; D'Incá, R.; Valpiani, D.; Russo, M. I.; Papi, C.; Fiorentini, M. T.; Ingrosso, M.; Andreoli, A.; Vecchi, M.; Morace, F.; Caserta, L.; Piscitelli, A.; Esposito, P.; Marmo, R.; Cantarini, D.; Gullini, S.; Di Paolo, M. C.; Pelli, M. A.; Garcea, R.; Novelli, G.; Mansi, C.; Annese, V.; Usai, P.; Assisi, D.; Frieri, G.; Pignatari, S.; Astegiano, M.; Pisani, A.; Mangiarotti, R.

In: Digestive Diseases and Sciences, Vol. 45, No. 3, 2000, p. 462-465.

Research output: Contribution to journalArticle

Riegler, G, Tartaglione, MT, Carratú, R, D'Incá, R, Valpiani, D, Russo, MI, Papi, C, Fiorentini, MT, Ingrosso, M, Andreoli, A, Vecchi, M, Morace, F, Caserta, L, Piscitelli, A, Esposito, P, Marmo, R, Cantarini, D, Gullini, S, Di Paolo, MC, Pelli, MA, Garcea, R, Novelli, G, Mansi, C, Annese, V, Usai, P, Assisi, D, Frieri, G, Pignatari, S, Astegiano, M, Pisani, A & Mangiarotti, R 2000, 'Age-related clinical severity at diagnosis in 1705 patients with ulcerative colitis: A study by GISC (Italian Colon-Rectum Study Group)', Digestive Diseases and Sciences, vol. 45, no. 3, pp. 462-465. https://doi.org/10.1023/A:1005424603085
Riegler, Gabriele ; Tartaglione, M. T. ; Carratú, R. ; D'Incá, R. ; Valpiani, D. ; Russo, M. I. ; Papi, C. ; Fiorentini, M. T. ; Ingrosso, M. ; Andreoli, A. ; Vecchi, M. ; Morace, F. ; Caserta, L. ; Piscitelli, A. ; Esposito, P. ; Marmo, R. ; Cantarini, D. ; Gullini, S. ; Di Paolo, M. C. ; Pelli, M. A. ; Garcea, R. ; Novelli, G. ; Mansi, C. ; Annese, V. ; Usai, P. ; Assisi, D. ; Frieri, G. ; Pignatari, S. ; Astegiano, M. ; Pisani, A. ; Mangiarotti, R. / Age-related clinical severity at diagnosis in 1705 patients with ulcerative colitis : A study by GISC (Italian Colon-Rectum Study Group). In: Digestive Diseases and Sciences. 2000 ; Vol. 45, No. 3. pp. 462-465.
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abstract = "Clinical-endoscopic parameters of UC presentation were studied in 1705 out-patients, observed consecutively in 17 Italian gastroenterology centers (males 60.2{\%}; average age at diagnosis 38.5 ± 16.4 years), and were subdivided arbitrarily into quartile age groups at diagnosis (0-25, 26-35, 36-50, >50). A significantly greater prevalence in males, increasing with age, was shown at diagnosis (P = 0.0002), which seems to correlate with the condition of being an ex-smoker, most frequently found in males. The greater frequency of exsmokers could also, in part, justify the second peak of incidence in old age. Greater colitis extent, greater clinical activity, and greater use of steroids as the first therapeutic step are shown to prevail among younger patients and among women (P = 0.02 and P = 0.019, respectively). The same is observed for symptoms mainly representing clinical severity such as diarrhea, fever, and weight loss (P = 0.004; P = 0.006; P = 0.009, respectively). This study confirms the UC risk factor represented by the condition of being an ex-smoker and shows a greater severity of illness on diagnosis in younger patients.",
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T1 - Age-related clinical severity at diagnosis in 1705 patients with ulcerative colitis

T2 - A study by GISC (Italian Colon-Rectum Study Group)

AU - Riegler, Gabriele

AU - Tartaglione, M. T.

AU - Carratú, R.

AU - D'Incá, R.

AU - Valpiani, D.

AU - Russo, M. I.

AU - Papi, C.

AU - Fiorentini, M. T.

AU - Ingrosso, M.

AU - Andreoli, A.

AU - Vecchi, M.

AU - Morace, F.

AU - Caserta, L.

AU - Piscitelli, A.

AU - Esposito, P.

AU - Marmo, R.

AU - Cantarini, D.

AU - Gullini, S.

AU - Di Paolo, M. C.

AU - Pelli, M. A.

AU - Garcea, R.

AU - Novelli, G.

AU - Mansi, C.

AU - Annese, V.

AU - Usai, P.

AU - Assisi, D.

AU - Frieri, G.

AU - Pignatari, S.

AU - Astegiano, M.

AU - Pisani, A.

AU - Mangiarotti, R.

PY - 2000

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KW - Smoking habit

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