Age-Related Differences in 1- and 12-Month Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation (from a Large Multicenter Data Repository)

Guilherme F. Attizzani, Yohei Ohno, Azeem Latib, Anna Sonia Petronio, Cristina Giannini, Federica Ettori, Claudia Fiorina, Francesco Bedogni, Nedy Brambilla, Giuseppe Bruschi, Paola Colombo, Patrizia Presbitero, Rosario Fiorilli, Arnaldo Poli, Marco Barbanti, Antonio Colombo, Corrado Tamburino

Research output: Contribution to journalArticle

Abstract

Scarce data are available on the impact of age on transcatheter aortic valve implantation (TAVI) outcomes. We therefore, analyzed 1,845 consecutive patients from 9 Italian centers who underwent TAVI with the Corevalve Revalving System from September 2007 to March 2014; patients were dichotomized according to their age in the date of the procedure, as follows: 75 to 85 years old and >85 years old. End points were defined according to Valve Academic Research Consortium definitions. In-hospital, 30-day, and 1-year clinical and echocardiographic data were available for 100% of the patients included. Propensity matching was performed. Procedural success rates were high (>94%) and comparable between groups. Although worse baseline renal function was observed in the older group, the incidence of acute kidney injury after procedure was comparable (17.1% and 17.4%, respectively for the 75- to 85- and >85-year-old group, p = 0.877); importantly, >99% of acute kidney injury episodes in both groups were grades 1 and 2. Procedural complications rates were low without between-group differences. In-hospital death (3.7% and 4.6%, p = 0.379) and stroke/transient ischemic attack (1.9% and 1.9%, respectively, p = 0.960) were comparable. The 1-year death rates were 14.9% and 17.2% (p = 0.197) in the 75- to 85- and >85-year-old group, respectively. Cardiovascular death was observed in 7.8% and 7% (p = 0.542), while stroke/transient ischemic attack was demonstrated in 5.2% and 4.4% (p = 0.496), respectively. Results were sustained after propensity matching. In conclusion, advanced age did not negatively impact the outcomes of TAVI through 1-year after procedure.

Original languageEnglish
Pages (from-to)1024-1030
Number of pages7
JournalAmerican Journal of Cardiology
Volume118
Issue number7
DOIs
Publication statusPublished - Oct 1 2016

    Fingerprint

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Attizzani, G. F., Ohno, Y., Latib, A., Petronio, A. S., Giannini, C., Ettori, F., Fiorina, C., Bedogni, F., Brambilla, N., Bruschi, G., Colombo, P., Presbitero, P., Fiorilli, R., Poli, A., Barbanti, M., Colombo, A., & Tamburino, C. (2016). Age-Related Differences in 1- and 12-Month Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation (from a Large Multicenter Data Repository). American Journal of Cardiology, 118(7), 1024-1030. https://doi.org/10.1016/j.amjcard.2016.07.018