Abstract
No datum is so far available on the relation between age and the acute glucose response to stress in women with ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI). We evaluated the age-related differences in the acute glucose response in 373 STEMI women submitted to PCI. The oldest women, when compared to the other age subgroups, showed the higher admission and peak glycemia (P0.001 and P0.001, respectively) in the lack of differences in insulin, C-peptide, hemoglobin-glycated values and discharge glycemia values. At logistic regression analysis, the following variables were independent predictors of in-Intensive Cardiac Care Unit mortality: age (1-year step) [odds ratio 1.09, 96% confidence interval (CI) 1.04-1.15, PU0.001], admission glycemia (1 g/l step) (odds ratio 2.05, 96% CI 1.35-3.12, P0.001). At Cox regression analysis the following variables were associated with 1-year mortality (when adjusted for discharge glycemia): age (1-year step) (hazard ratio 1.13, 95% CI 1.04-1.22, PU0.005), estimated glomerular filtration rate (1 g/l step) (hazard ratio 0.93, 95% CI 0.90-0.96, P0.001). Age affects the acute glucose response to myocardial injury since older women showed the higher admission glucose values and the poorer in-hospital glucose control, in the lack of differences of insulin-resistance incidence. Glucose values were independent predictors of in-hospital mortality, but were not related to long-term survival.
| Original language | English |
|---|---|
| Pages (from-to) | 321-325 |
| Number of pages | 5 |
| Journal | Journal of Cardiovascular Medicine |
| Volume | 16 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 7 2015 |
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Keywords
- age
- glucose
- percutaneous coronary intervention
- prognosis
- ST-elevation myocardial infarction
- women
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Age-related differences in glucose abnormalities in women with ST-elevation myocardial infarction submitted to percutaneous coronary intervention : A single-center experience. / Lazzeri, Chiara; Gensini, Gian Franco; D'Alfonso, Maria Grazia; Chiostri, Marco; Attana, Paola; Valente, Serafina.
In: Journal of Cardiovascular Medicine, Vol. 16, No. 5, 07.05.2015, p. 321-325.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-related differences in glucose abnormalities in women with ST-elevation myocardial infarction submitted to percutaneous coronary intervention
T2 - A single-center experience
AU - Lazzeri, Chiara
AU - Gensini, Gian Franco
AU - D'Alfonso, Maria Grazia
AU - Chiostri, Marco
AU - Attana, Paola
AU - Valente, Serafina
PY - 2015/5/7
Y1 - 2015/5/7
N2 - No datum is so far available on the relation between age and the acute glucose response to stress in women with ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI). We evaluated the age-related differences in the acute glucose response in 373 STEMI women submitted to PCI. The oldest women, when compared to the other age subgroups, showed the higher admission and peak glycemia (P0.001 and P0.001, respectively) in the lack of differences in insulin, C-peptide, hemoglobin-glycated values and discharge glycemia values. At logistic regression analysis, the following variables were independent predictors of in-Intensive Cardiac Care Unit mortality: age (1-year step) [odds ratio 1.09, 96% confidence interval (CI) 1.04-1.15, PU0.001], admission glycemia (1 g/l step) (odds ratio 2.05, 96% CI 1.35-3.12, P0.001). At Cox regression analysis the following variables were associated with 1-year mortality (when adjusted for discharge glycemia): age (1-year step) (hazard ratio 1.13, 95% CI 1.04-1.22, PU0.005), estimated glomerular filtration rate (1 g/l step) (hazard ratio 0.93, 95% CI 0.90-0.96, P0.001). Age affects the acute glucose response to myocardial injury since older women showed the higher admission glucose values and the poorer in-hospital glucose control, in the lack of differences of insulin-resistance incidence. Glucose values were independent predictors of in-hospital mortality, but were not related to long-term survival.
AB - No datum is so far available on the relation between age and the acute glucose response to stress in women with ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI). We evaluated the age-related differences in the acute glucose response in 373 STEMI women submitted to PCI. The oldest women, when compared to the other age subgroups, showed the higher admission and peak glycemia (P0.001 and P0.001, respectively) in the lack of differences in insulin, C-peptide, hemoglobin-glycated values and discharge glycemia values. At logistic regression analysis, the following variables were independent predictors of in-Intensive Cardiac Care Unit mortality: age (1-year step) [odds ratio 1.09, 96% confidence interval (CI) 1.04-1.15, PU0.001], admission glycemia (1 g/l step) (odds ratio 2.05, 96% CI 1.35-3.12, P0.001). At Cox regression analysis the following variables were associated with 1-year mortality (when adjusted for discharge glycemia): age (1-year step) (hazard ratio 1.13, 95% CI 1.04-1.22, PU0.005), estimated glomerular filtration rate (1 g/l step) (hazard ratio 0.93, 95% CI 0.90-0.96, P0.001). Age affects the acute glucose response to myocardial injury since older women showed the higher admission glucose values and the poorer in-hospital glucose control, in the lack of differences of insulin-resistance incidence. Glucose values were independent predictors of in-hospital mortality, but were not related to long-term survival.
KW - age
KW - glucose
KW - percutaneous coronary intervention
KW - prognosis
KW - ST-elevation myocardial infarction
KW - women
UR - http://www.scopus.com/inward/record.url?scp=84926417532&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926417532&partnerID=8YFLogxK
U2 - 10.2459/JCM.0000000000000003
DO - 10.2459/JCM.0000000000000003
M3 - Article
C2 - 24911194
AN - SCOPUS:84926417532
VL - 16
SP - 321
EP - 325
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
SN - 1558-2027
IS - 5
ER -