Age-related differences in glucose abnormalities in women with ST-elevation myocardial infarction submitted to percutaneous coronary intervention: A single-center experience

Chiara Lazzeri, Gian Franco Gensini, Maria Grazia D'Alfonso, Marco Chiostri, Paola Attana, Serafina Valente

Research output: Contribution to journalArticle

Abstract

No datum is so far available on the relation between age and the acute glucose response to stress in women with ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI). We evaluated the age-related differences in the acute glucose response in 373 STEMI women submitted to PCI. The oldest women, when compared to the other age subgroups, showed the higher admission and peak glycemia (P0.001 and P0.001, respectively) in the lack of differences in insulin, C-peptide, hemoglobin-glycated values and discharge glycemia values. At logistic regression analysis, the following variables were independent predictors of in-Intensive Cardiac Care Unit mortality: age (1-year step) [odds ratio 1.09, 96% confidence interval (CI) 1.04-1.15, PU0.001], admission glycemia (1 g/l step) (odds ratio 2.05, 96% CI 1.35-3.12, P0.001). At Cox regression analysis the following variables were associated with 1-year mortality (when adjusted for discharge glycemia): age (1-year step) (hazard ratio 1.13, 95% CI 1.04-1.22, PU0.005), estimated glomerular filtration rate (1 g/l step) (hazard ratio 0.93, 95% CI 0.90-0.96, P0.001). Age affects the acute glucose response to myocardial injury since older women showed the higher admission glucose values and the poorer in-hospital glucose control, in the lack of differences of insulin-resistance incidence. Glucose values were independent predictors of in-hospital mortality, but were not related to long-term survival.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalJournal of Cardiovascular Medicine
Volume16
Issue number5
DOIs
Publication statusPublished - May 7 2015

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Percutaneous Coronary Intervention
Glucose
Confidence Intervals
Odds Ratio
Regression Analysis
Mortality
C-Peptide
Glycosylated Hemoglobin A
Hospital Mortality
Glomerular Filtration Rate
Intensive Care Units
Insulin Resistance
ST Elevation Myocardial Infarction
Logistic Models
Insulin
Survival
Incidence
Wounds and Injuries

Keywords

  • age
  • glucose
  • percutaneous coronary intervention
  • prognosis
  • ST-elevation myocardial infarction
  • women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Age-related differences in glucose abnormalities in women with ST-elevation myocardial infarction submitted to percutaneous coronary intervention : A single-center experience. / Lazzeri, Chiara; Gensini, Gian Franco; D'Alfonso, Maria Grazia; Chiostri, Marco; Attana, Paola; Valente, Serafina.

In: Journal of Cardiovascular Medicine, Vol. 16, No. 5, 07.05.2015, p. 321-325.

Research output: Contribution to journalArticle

Lazzeri, Chiara ; Gensini, Gian Franco ; D'Alfonso, Maria Grazia ; Chiostri, Marco ; Attana, Paola ; Valente, Serafina. / Age-related differences in glucose abnormalities in women with ST-elevation myocardial infarction submitted to percutaneous coronary intervention : A single-center experience. In: Journal of Cardiovascular Medicine. 2015 ; Vol. 16, No. 5. pp. 321-325.
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