Age-related differences in kinetics and side-effects of viloxazine in man and their clinical implications

A. C. Altamura; T. Melorio; G. Invernizzi; F. Colacurcio; R. Gomeni

doi:10.1007/BF00427563

Age-related differences in kinetics and side-effects of viloxazine in man and their clinical implications

A. C. Altamura, T. Melorio, G. Invernizzi, F. Colacurcio, R. Gomeni

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Dose kinetics and side effects of viloxazine (VLX) in 16 healthy volunteers (range age 25-90 years) were studied after single oral administration of 200 mg of VLX. Significant differences in peak plasma values (P1/2 (P1/2 and Cl/F, due to the high interindividual variability in pharmacokinetic profiles. Total reported and observed side effects scores were higher overall in subjects under 50 years than over 60 years and were inversely correlated to AUC (P

Original language	English
Pages (from-to)	281-285
Number of pages	5
Journal	Psychopharmacology
Volume	81
Issue number	4
DOIs	https://doi.org/10.1007/BF00427563
Publication status	Published - Nov 1983

Keywords

Age
Metabolites
Pharmacokinetics
Side effects
Viloxazine

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00427563

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author = "Altamura, {A. C.} and T. Melorio and G. Invernizzi and F. Colacurcio and R. Gomeni",

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AU - Altamura, A. C.

AU - Melorio, T.

AU - Invernizzi, G.

AU - Colacurcio, F.

AU - Gomeni, R.

PY - 1983/11

Y1 - 1983/11

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AB - Dose kinetics and side effects of viloxazine (VLX) in 16 healthy volunteers (range age 25-90 years) were studied after single oral administration of 200 mg of VLX. Significant differences in peak plasma values (P1/2 (P1/2 and Cl/F, due to the high interindividual variability in pharmacokinetic profiles. Total reported and observed side effects scores were higher overall in subjects under 50 years than over 60 years and were inversely correlated to AUC (P

KW - Age

KW - Metabolites

KW - Pharmacokinetics

KW - Side effects

KW - Viloxazine

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Age-related differences in kinetics and side-effects of viloxazine in man and their clinical implications

Abstract

Keywords

ASJC Scopus subject areas

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