Age-related differences in kinetics and side-effects of viloxazine in man and their clinical implications

A. C. Altamura, T. Melorio, G. Invernizzi, F. Colacurcio, R. Gomeni

Research output: Contribution to journal › Article › peer-review

Abstract

Dose kinetics and side effects of viloxazine (VLX) in 16 healthy volunteers (range age 25-90 years) were studied after single oral administration of 200 mg of VLX. Significant differences in peak plasma values (P1/2 (P1/2 and Cl/F, due to the high interindividual variability in pharmacokinetic profiles. Total reported and observed side effects scores were higher overall in subjects under 50 years than over 60 years and were inversely correlated to AUC (P

Original languageEnglish
Pages (from-to)281-285
Number of pages5
JournalPsychopharmacology
Volume81
Issue number4
DOIs
Publication statusPublished - Nov 1983

Keywords

  • Age
  • Metabolites
  • Pharmacokinetics
  • Side effects
  • Viloxazine

ASJC Scopus subject areas

  • Pharmacology

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