Age-related effect of ritanserin on the sleep-waking phases in rats

Roumen Kirov, Slavianka Moyanova

Research output: Contribution to journalArticle

Abstract

The age-related effect of the specific 5-hydroxytryptamine-2A/2C (5-HT(2A/2C)) antagonist ritanserin at two doses (0.63 mg/kg and 2.5 mg/kg) on six sleep-waking phases in young, middle-aged, and old male Wistar rats was electroencephalographically (EEG) examined. Only in the young and middleaged rats, ritanserin enhanced slow wave sleep and reduced wakefulness in a dose-dependent manner. Ritanserin suppressed paradoxical sleep, such that this effect did not depend on the age. Although the effect of ritanserin on slow wave sleep was significantly smaller in the old compared to the young and the middle-aged rats, ritanserin produced an apparent sleep-improving effect in the old age group.

Original languageEnglish
Pages (from-to)265-278
Number of pages14
JournalInternational Journal of Neuroscience
Volume93
Issue number3-4
Publication statusPublished - Apr 1998

Fingerprint

Ritanserin
Sleep
Serotonin
Wakefulness
REM Sleep
Wistar Rats
Age Groups

Keywords

  • 5-HT receptors
  • Aging
  • EEG, rats
  • Ritanserin
  • Sleep-waking phases

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Age-related effect of ritanserin on the sleep-waking phases in rats. / Kirov, Roumen; Moyanova, Slavianka.

In: International Journal of Neuroscience, Vol. 93, No. 3-4, 04.1998, p. 265-278.

Research output: Contribution to journalArticle

Kirov, Roumen ; Moyanova, Slavianka. / Age-related effect of ritanserin on the sleep-waking phases in rats. In: International Journal of Neuroscience. 1998 ; Vol. 93, No. 3-4. pp. 265-278.
@article{4c4942d25c894db09c947cb8c771fdb8,
title = "Age-related effect of ritanserin on the sleep-waking phases in rats",
abstract = "The age-related effect of the specific 5-hydroxytryptamine-2A/2C (5-HT(2A/2C)) antagonist ritanserin at two doses (0.63 mg/kg and 2.5 mg/kg) on six sleep-waking phases in young, middle-aged, and old male Wistar rats was electroencephalographically (EEG) examined. Only in the young and middleaged rats, ritanserin enhanced slow wave sleep and reduced wakefulness in a dose-dependent manner. Ritanserin suppressed paradoxical sleep, such that this effect did not depend on the age. Although the effect of ritanserin on slow wave sleep was significantly smaller in the old compared to the young and the middle-aged rats, ritanserin produced an apparent sleep-improving effect in the old age group.",
keywords = "5-HT receptors, Aging, EEG, rats, Ritanserin, Sleep-waking phases",
author = "Roumen Kirov and Slavianka Moyanova",
year = "1998",
month = "4",
language = "English",
volume = "93",
pages = "265--278",
journal = "International Journal of Neuroscience",
issn = "0020-7454",
publisher = "Informa Healthcare",
number = "3-4",

}

TY - JOUR

T1 - Age-related effect of ritanserin on the sleep-waking phases in rats

AU - Kirov, Roumen

AU - Moyanova, Slavianka

PY - 1998/4

Y1 - 1998/4

N2 - The age-related effect of the specific 5-hydroxytryptamine-2A/2C (5-HT(2A/2C)) antagonist ritanserin at two doses (0.63 mg/kg and 2.5 mg/kg) on six sleep-waking phases in young, middle-aged, and old male Wistar rats was electroencephalographically (EEG) examined. Only in the young and middleaged rats, ritanserin enhanced slow wave sleep and reduced wakefulness in a dose-dependent manner. Ritanserin suppressed paradoxical sleep, such that this effect did not depend on the age. Although the effect of ritanserin on slow wave sleep was significantly smaller in the old compared to the young and the middle-aged rats, ritanserin produced an apparent sleep-improving effect in the old age group.

AB - The age-related effect of the specific 5-hydroxytryptamine-2A/2C (5-HT(2A/2C)) antagonist ritanserin at two doses (0.63 mg/kg and 2.5 mg/kg) on six sleep-waking phases in young, middle-aged, and old male Wistar rats was electroencephalographically (EEG) examined. Only in the young and middleaged rats, ritanserin enhanced slow wave sleep and reduced wakefulness in a dose-dependent manner. Ritanserin suppressed paradoxical sleep, such that this effect did not depend on the age. Although the effect of ritanserin on slow wave sleep was significantly smaller in the old compared to the young and the middle-aged rats, ritanserin produced an apparent sleep-improving effect in the old age group.

KW - 5-HT receptors

KW - Aging

KW - EEG, rats

KW - Ritanserin

KW - Sleep-waking phases

UR - http://www.scopus.com/inward/record.url?scp=0032052671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032052671&partnerID=8YFLogxK

M3 - Article

C2 - 9639244

AN - SCOPUS:0032052671

VL - 93

SP - 265

EP - 278

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

SN - 0020-7454

IS - 3-4

ER -