Abstract
Background and Purpose - Atherosclerosis occurs later and is less extensive in intracranial arteries than in extracranial arteries. However, the mechanisms responsible are poorly understood. A previous study has suggested a better antioxidant protection of intracranial arteries. Methods - To assess the influence of age on arterial activity of antioxidant enzymes and atherogenesis, we compared intracranial and extracranial arteries of humans of different ages who retrospectively lacked confounding classic risk factors (48 premature fetuses aged 6.4±0.8 months [mean±SD], 58 children aged 7.9±3.8 years, 42 adults aged 42.5±5.1 years, and 40 elderly subjects aged 71.8±3.4 years; all males). Lesions were quantified by computer-assisted imaging analysis of sections of the middle cerebral and basilar arteries, the left anterior descending coronary artery, the common carotid artery, and the abdominal aorta. Macrophages, apolipoprotein B, oxidized LDL, and matrix metalloproteinase-9 in lesions were determined by immunocytochemistry. The effect of aging on atherogenesis was then compared with that on the activity of 4 antioxidant enzymes in the arterial wall. Results - Atherosclerosis was 6- to 19-fold greater (P
| Original language | English |
|---|---|
| Pages (from-to) | 2472-2478 |
| Number of pages | 7 |
| Journal | Stroke |
| Volume | 32 |
| Issue number | 11 |
| Publication status | Published - 2001 |
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Keywords
- Atherosclerosis
- Cerebral arteries
- Lipoproteins, LDL
- Oxygen radical
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Neuroscience(all)
- Medicine(all)
Cite this
Age-related effects on atherogenesis and scavenger enzymes of intracranial and extracranial arteries in men without classic risk factors for atherosclerosis. / D'Armiento, Francesco P.; Bianchi, Alfredo; De Nigris, Filomena; Capuzzi, David M.; D'Armiento, Maria R.; Crimi, Giuseppe; Abete, Pasquale; Palinski, Wulf; Condorelli, Mario; Napoli, Claudio.
In: Stroke, Vol. 32, No. 11, 2001, p. 2472-2478.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-related effects on atherogenesis and scavenger enzymes of intracranial and extracranial arteries in men without classic risk factors for atherosclerosis
AU - D'Armiento, Francesco P.
AU - Bianchi, Alfredo
AU - De Nigris, Filomena
AU - Capuzzi, David M.
AU - D'Armiento, Maria R.
AU - Crimi, Giuseppe
AU - Abete, Pasquale
AU - Palinski, Wulf
AU - Condorelli, Mario
AU - Napoli, Claudio
PY - 2001
Y1 - 2001
N2 - Background and Purpose - Atherosclerosis occurs later and is less extensive in intracranial arteries than in extracranial arteries. However, the mechanisms responsible are poorly understood. A previous study has suggested a better antioxidant protection of intracranial arteries. Methods - To assess the influence of age on arterial activity of antioxidant enzymes and atherogenesis, we compared intracranial and extracranial arteries of humans of different ages who retrospectively lacked confounding classic risk factors (48 premature fetuses aged 6.4±0.8 months [mean±SD], 58 children aged 7.9±3.8 years, 42 adults aged 42.5±5.1 years, and 40 elderly subjects aged 71.8±3.4 years; all males). Lesions were quantified by computer-assisted imaging analysis of sections of the middle cerebral and basilar arteries, the left anterior descending coronary artery, the common carotid artery, and the abdominal aorta. Macrophages, apolipoprotein B, oxidized LDL, and matrix metalloproteinase-9 in lesions were determined by immunocytochemistry. The effect of aging on atherogenesis was then compared with that on the activity of 4 antioxidant enzymes in the arterial wall. Results - Atherosclerosis was 6- to 19-fold greater (P
AB - Background and Purpose - Atherosclerosis occurs later and is less extensive in intracranial arteries than in extracranial arteries. However, the mechanisms responsible are poorly understood. A previous study has suggested a better antioxidant protection of intracranial arteries. Methods - To assess the influence of age on arterial activity of antioxidant enzymes and atherogenesis, we compared intracranial and extracranial arteries of humans of different ages who retrospectively lacked confounding classic risk factors (48 premature fetuses aged 6.4±0.8 months [mean±SD], 58 children aged 7.9±3.8 years, 42 adults aged 42.5±5.1 years, and 40 elderly subjects aged 71.8±3.4 years; all males). Lesions were quantified by computer-assisted imaging analysis of sections of the middle cerebral and basilar arteries, the left anterior descending coronary artery, the common carotid artery, and the abdominal aorta. Macrophages, apolipoprotein B, oxidized LDL, and matrix metalloproteinase-9 in lesions were determined by immunocytochemistry. The effect of aging on atherogenesis was then compared with that on the activity of 4 antioxidant enzymes in the arterial wall. Results - Atherosclerosis was 6- to 19-fold greater (P
KW - Atherosclerosis
KW - Cerebral arteries
KW - Lipoproteins, LDL
KW - Oxygen radical
UR - http://www.scopus.com/inward/record.url?scp=0035168776&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035168776&partnerID=8YFLogxK
M3 - Article
C2 - 11692003
AN - SCOPUS:0035168776
VL - 32
SP - 2472
EP - 2478
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 11
ER -