Age-related epigenetic derangement upon reprogramming and differentiation of cells from the elderly

Francesco Ravaioli, Maria G. Bacalini, Claudio Franceschi, Paolo Garagnani

Research output: Contribution to journalReview article

Abstract

Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of studies have been describing the generation of induced pluripotent stem cells (iPSCs) from old or centenarian biologic material. Nonetheless, reprogramming techniques determine a profound remodelling on cell epigenetic architecture whose extent is still largely debated. Given that cell epigenetic profile changes with age, the study of cell-fate manipulation approaches on cells deriving from old donors or centenarians may provide new insights not only on regenerative features and physiology of these cells, but also on reprogramming-associated and age-related epigenetic derangement.

Original languageEnglish
Article number39
JournalGenes
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 16 2018

Keywords

  • Aging
  • Cell reprogramming
  • DNA methylation
  • Induced Pluripotent Stem Cells

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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