Age-related inflammation: The contribution of different organs, tissues and systems. How to face it for therapeutic approaches

E. Cevenini; C. Caruso; G. Candore; M. Capri; D. Nuzzo; G. Duro; C. Rizzo; G. Colonna-Romano; D. Lio; D. Di Carlo; M. G. Palmas; M. Scurti; E. Pini; C. Franceschi; S. Vasto

doi:10.2174/138161210790883840

Age-related inflammation: The contribution of different organs, tissues and systems. How to face it for therapeutic approaches

E. Cevenini, C. Caruso, G. Candore, M. Capri, D. Nuzzo, G. Duro, C. Rizzo, G. Colonna-Romano, D. Lio, D. Di Carlo, M. G. Palmas, M. Scurti, E. Pini, C. Franceschi, S. Vasto

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

A typical feature of ageing is a chronic, low-grade inflammation characterized by a general increase in the production of pro-inflammatory cytokines and inflammatory markers ("inflamm-ageing"). This status may slowly damage one or several organs, especially when unfavorable genetic polymorphisms and epigenetic alterations are concomitant, leading to an increased risk of frailty together with the onset of age-related chronic diseases. The contribution of different tissues (adipose tissue, muscle), organs (brain, liver), immune system and ecosystems (gut microbiota) to age-related inflammation ("inflamm-ageing") will be discussed in this review in the context of its onset/progression leading to site-restricted and systemic effects. Moreover, some of the possible strategies and therapies to counteract the different sources of molecular mediators which lead to the age-related inflammatory phenotype will be presented.

Original language	English
Pages (from-to)	609-618
Number of pages	10
Journal	Current Pharmaceutical Design
Volume	16
Issue number	6
DOIs	https://doi.org/10.2174/138161210790883840
Publication status	Published - 2010

Keywords

Age-related diseases
Ageing
Immunosenescence
Inflammation

ASJC Scopus subject areas

Drug Discovery
Pharmacology
Medicine(all)

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10.2174/138161210790883840

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Cevenini, E., Caruso, C., Candore, G., Capri, M., Nuzzo, D., Duro, G., Rizzo, C., Colonna-Romano, G., Lio, D., Di Carlo, D., Palmas, M. G., Scurti, M., Pini, E., Franceschi, C., & Vasto, S. (2010). Age-related inflammation: The contribution of different organs, tissues and systems. How to face it for therapeutic approaches. Current Pharmaceutical Design, 16(6), 609-618. https://doi.org/10.2174/138161210790883840

Age-related inflammation : The contribution of different organs, tissues and systems. How to face it for therapeutic approaches. / Cevenini, E.; Caruso, C.; Candore, G.; Capri, M.; Nuzzo, D.; Duro, G.; Rizzo, C.; Colonna-Romano, G.; Lio, D.; Di Carlo, D.; Palmas, M. G.; Scurti, M.; Pini, E.; Franceschi, C.; Vasto, S.

In: Current Pharmaceutical Design, Vol. 16, No. 6, 2010, p. 609-618.

Research output: Contribution to journal › Article › peer-review

Cevenini, E, Caruso, C, Candore, G, Capri, M, Nuzzo, D, Duro, G, Rizzo, C, Colonna-Romano, G, Lio, D, Di Carlo, D, Palmas, MG, Scurti, M, Pini, E, Franceschi, C & Vasto, S 2010, 'Age-related inflammation: The contribution of different organs, tissues and systems. How to face it for therapeutic approaches', Current Pharmaceutical Design, vol. 16, no. 6, pp. 609-618. https://doi.org/10.2174/138161210790883840

Cevenini, E. ; Caruso, C. ; Candore, G. ; Capri, M. ; Nuzzo, D. ; Duro, G. ; Rizzo, C. ; Colonna-Romano, G. ; Lio, D. ; Di Carlo, D. ; Palmas, M. G. ; Scurti, M. ; Pini, E. ; Franceschi, C. ; Vasto, S. / Age-related inflammation : The contribution of different organs, tissues and systems. How to face it for therapeutic approaches. In: Current Pharmaceutical Design. 2010 ; Vol. 16, No. 6. pp. 609-618.

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