Age-related inflammation: The contribution of different organs, tissues and systems. How to face it for therapeutic approaches

E. Cevenini, C. Caruso, G. Candore, M. Capri, D. Nuzzo, G. Duro, C. Rizzo, G. Colonna-Romano, D. Lio, D. Di Carlo, M. G. Palmas, M. Scurti, E. Pini, C. Franceschi, S. Vasto

Research output: Contribution to journalArticlepeer-review

Abstract

A typical feature of ageing is a chronic, low-grade inflammation characterized by a general increase in the production of pro-inflammatory cytokines and inflammatory markers ("inflamm-ageing"). This status may slowly damage one or several organs, especially when unfavorable genetic polymorphisms and epigenetic alterations are concomitant, leading to an increased risk of frailty together with the onset of age-related chronic diseases. The contribution of different tissues (adipose tissue, muscle), organs (brain, liver), immune system and ecosystems (gut microbiota) to age-related inflammation ("inflamm-ageing") will be discussed in this review in the context of its onset/progression leading to site-restricted and systemic effects. Moreover, some of the possible strategies and therapies to counteract the different sources of molecular mediators which lead to the age-related inflammatory phenotype will be presented.

Original languageEnglish
Pages (from-to)609-618
Number of pages10
JournalCurrent Pharmaceutical Design
Volume16
Issue number6
DOIs
Publication statusPublished - 2010

Keywords

  • Age-related diseases
  • Ageing
  • Immunosenescence
  • Inflammation

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Medicine(all)

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