Age-related iron deposition in the basal ganglia: Quantitative analysis in healthy subjects

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Abstract

Purpose: To determine the values of iron accumulation in the basal ganglia of healthy volunteers of different ages with R2* and raw signal intensity measurements from T1-weighted magnetic resonance (MR) images, supported by voxel-based relaxometry (VBR), and to compare them with previously reported iron concentrations found in autopsy material. Materials and Methods: The ethics committee approved the study, and the participants or their parents gave written informed consent. Eighty subjects (41 female and 39 male subjects; age range, 1-80 years) were examined at 1.5 T. For each subject, R2* values were calculated. Curves for R2* versus age were obtained for globus pallidus (GP), putamen, caudate nucleus, substantia nigra (SN), and frontal white matter (FWM). To highlight possible differences in iron concentration among the age decades, VBR was applied. Signal intensity values were estimated on T1-weighted fast low-angle shot images, and regions of interest were drawn in each nucleus. R2* values were also compared with iron concentrations reported in a postmortem study. Statistical analysis was performed (t test), and a difference with P <.05 (FDR corrected) was significant. Results: The curves for R2* versus age showed an exponential increase with increasing age in all the basal ganglia. VBR demonstrated significant differences (P <.05, corrected) in the comparison between the 2nd and the following decades for lenticular nuclei. Good correlation coefficients were found for GP (R 2 = 0.64), putamen (R2 = 0.51), and SN (R2 = 0.53) when compared with findings in the post-mortem study. Signal intensity curves were similar to the R2* curves. Conclusion: R2* measurements can be used to quantify brain iron accumulation and thus may allow better evaluation of neurodegenerative diseases associated with iron deposition.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalRadiology
Volume252
Issue number1
DOIs
Publication statusPublished - Jul 2009

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Basal Ganglia
Healthy Volunteers
Iron
Globus Pallidus
Putamen
Substantia Nigra
Corpus Striatum
Ethics Committees
Caudate Nucleus
Informed Consent
Neurodegenerative Diseases
Autopsy
Magnetic Resonance Spectroscopy
Parents
Brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Age-related iron deposition in the basal ganglia: Quantitative analysis in healthy subjects",
abstract = "Purpose: To determine the values of iron accumulation in the basal ganglia of healthy volunteers of different ages with R2* and raw signal intensity measurements from T1-weighted magnetic resonance (MR) images, supported by voxel-based relaxometry (VBR), and to compare them with previously reported iron concentrations found in autopsy material. Materials and Methods: The ethics committee approved the study, and the participants or their parents gave written informed consent. Eighty subjects (41 female and 39 male subjects; age range, 1-80 years) were examined at 1.5 T. For each subject, R2* values were calculated. Curves for R2* versus age were obtained for globus pallidus (GP), putamen, caudate nucleus, substantia nigra (SN), and frontal white matter (FWM). To highlight possible differences in iron concentration among the age decades, VBR was applied. Signal intensity values were estimated on T1-weighted fast low-angle shot images, and regions of interest were drawn in each nucleus. R2* values were also compared with iron concentrations reported in a postmortem study. Statistical analysis was performed (t test), and a difference with P <.05 (FDR corrected) was significant. Results: The curves for R2* versus age showed an exponential increase with increasing age in all the basal ganglia. VBR demonstrated significant differences (P <.05, corrected) in the comparison between the 2nd and the following decades for lenticular nuclei. Good correlation coefficients were found for GP (R 2 = 0.64), putamen (R2 = 0.51), and SN (R2 = 0.53) when compared with findings in the post-mortem study. Signal intensity curves were similar to the R2* curves. Conclusion: R2* measurements can be used to quantify brain iron accumulation and thus may allow better evaluation of neurodegenerative diseases associated with iron deposition.",
author = "Domenico Aquino and Alberto Bizzi and Marina Grisoli and Barbara Garavaglia and Bruzzone, {Maria Grazia} and Nardo Nardocci and Mario Savoiardo and Luisa Chiapparini",
year = "2009",
month = "7",
doi = "10.1148/radiol.2522081399",
language = "English",
volume = "252",
pages = "165--172",
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T1 - Age-related iron deposition in the basal ganglia

T2 - Quantitative analysis in healthy subjects

AU - Aquino, Domenico

AU - Bizzi, Alberto

AU - Grisoli, Marina

AU - Garavaglia, Barbara

AU - Bruzzone, Maria Grazia

AU - Nardocci, Nardo

AU - Savoiardo, Mario

AU - Chiapparini, Luisa

PY - 2009/7

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N2 - Purpose: To determine the values of iron accumulation in the basal ganglia of healthy volunteers of different ages with R2* and raw signal intensity measurements from T1-weighted magnetic resonance (MR) images, supported by voxel-based relaxometry (VBR), and to compare them with previously reported iron concentrations found in autopsy material. Materials and Methods: The ethics committee approved the study, and the participants or their parents gave written informed consent. Eighty subjects (41 female and 39 male subjects; age range, 1-80 years) were examined at 1.5 T. For each subject, R2* values were calculated. Curves for R2* versus age were obtained for globus pallidus (GP), putamen, caudate nucleus, substantia nigra (SN), and frontal white matter (FWM). To highlight possible differences in iron concentration among the age decades, VBR was applied. Signal intensity values were estimated on T1-weighted fast low-angle shot images, and regions of interest were drawn in each nucleus. R2* values were also compared with iron concentrations reported in a postmortem study. Statistical analysis was performed (t test), and a difference with P <.05 (FDR corrected) was significant. Results: The curves for R2* versus age showed an exponential increase with increasing age in all the basal ganglia. VBR demonstrated significant differences (P <.05, corrected) in the comparison between the 2nd and the following decades for lenticular nuclei. Good correlation coefficients were found for GP (R 2 = 0.64), putamen (R2 = 0.51), and SN (R2 = 0.53) when compared with findings in the post-mortem study. Signal intensity curves were similar to the R2* curves. Conclusion: R2* measurements can be used to quantify brain iron accumulation and thus may allow better evaluation of neurodegenerative diseases associated with iron deposition.

AB - Purpose: To determine the values of iron accumulation in the basal ganglia of healthy volunteers of different ages with R2* and raw signal intensity measurements from T1-weighted magnetic resonance (MR) images, supported by voxel-based relaxometry (VBR), and to compare them with previously reported iron concentrations found in autopsy material. Materials and Methods: The ethics committee approved the study, and the participants or their parents gave written informed consent. Eighty subjects (41 female and 39 male subjects; age range, 1-80 years) were examined at 1.5 T. For each subject, R2* values were calculated. Curves for R2* versus age were obtained for globus pallidus (GP), putamen, caudate nucleus, substantia nigra (SN), and frontal white matter (FWM). To highlight possible differences in iron concentration among the age decades, VBR was applied. Signal intensity values were estimated on T1-weighted fast low-angle shot images, and regions of interest were drawn in each nucleus. R2* values were also compared with iron concentrations reported in a postmortem study. Statistical analysis was performed (t test), and a difference with P <.05 (FDR corrected) was significant. Results: The curves for R2* versus age showed an exponential increase with increasing age in all the basal ganglia. VBR demonstrated significant differences (P <.05, corrected) in the comparison between the 2nd and the following decades for lenticular nuclei. Good correlation coefficients were found for GP (R 2 = 0.64), putamen (R2 = 0.51), and SN (R2 = 0.53) when compared with findings in the post-mortem study. Signal intensity curves were similar to the R2* curves. Conclusion: R2* measurements can be used to quantify brain iron accumulation and thus may allow better evaluation of neurodegenerative diseases associated with iron deposition.

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