TY - JOUR
T1 - Age-Related Macular Degeneration
T2 - Insights into Inflammatory Genes
AU - Cascella, Raffaella
AU - Ragazzo, Michele
AU - Strafella, Claudia
AU - Missiroli, Filippo
AU - Borgiani, Paola
AU - Angelucci, Francesco
AU - Marsella, Luigi Tonino
AU - Cusumano, Andrea
AU - Novelli, Giuseppe
AU - Ricci, Federico
AU - Giardina, Emiliano
PY - 2014
Y1 - 2014
N2 - Age-related macular degeneration (AMD) is a progressive neurodegenerative disease that affects approximately 8.7% of elderly people worldwide (>55 years old). AMD is characterized by a multifactorial aetiology that involves several genetic and environmental risk factors (genes, ageing, smoking, family history, dietary habits, oxidative stress, and hypertension). In particular, ageing and cigarette smoking (including oxidative compounds and reactive oxygen species) have been shown to significantly increase susceptibility to the disease. Furthermore, different genes (CFH, CFI, C2, C3, IL-6, IL-8, and ARMS2) that play a crucial role in the inflammatory pathway have been associated with AMD risk. Several genetic and molecular studies have indicated the participation of inflammatory molecules (cytokines and chemokines), immune cells (macrophages), and complement proteins in the development and progression of the disease. Taking into consideration the genetic and molecular background, this review highlights the genetic role of inflammatory genes involved in AMD pathogenesis and progression.
AB - Age-related macular degeneration (AMD) is a progressive neurodegenerative disease that affects approximately 8.7% of elderly people worldwide (>55 years old). AMD is characterized by a multifactorial aetiology that involves several genetic and environmental risk factors (genes, ageing, smoking, family history, dietary habits, oxidative stress, and hypertension). In particular, ageing and cigarette smoking (including oxidative compounds and reactive oxygen species) have been shown to significantly increase susceptibility to the disease. Furthermore, different genes (CFH, CFI, C2, C3, IL-6, IL-8, and ARMS2) that play a crucial role in the inflammatory pathway have been associated with AMD risk. Several genetic and molecular studies have indicated the participation of inflammatory molecules (cytokines and chemokines), immune cells (macrophages), and complement proteins in the development and progression of the disease. Taking into consideration the genetic and molecular background, this review highlights the genetic role of inflammatory genes involved in AMD pathogenesis and progression.
UR - http://www.scopus.com/inward/record.url?scp=84912058346&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84912058346&partnerID=8YFLogxK
U2 - 10.1155/2014/582842
DO - 10.1155/2014/582842
M3 - Article
AN - SCOPUS:84912058346
VL - 2014
JO - Journal of Ophthalmology
JF - Journal of Ophthalmology
SN - 2090-004X
M1 - 582842
ER -