TY - JOUR
T1 - Age-related modifications in circulating IL-15 levels in humans
AU - Gangemi, Sebastiano
AU - Basile, Giorgio
AU - Monti, Daniela
AU - Merendino, Rosaria Alba
AU - Di Pasquale, Giuseppe
AU - Bisignano, Ursula
AU - Nicita-Mauro, Vittorio
AU - Franceschi, Claudio
PY - 2005/8/31
Y1 - 2005/8/31
N2 - Aging is associated to a progressive establishing of a chronic inflammatory state linked to a continuous long exposure to antigens. Since IL-15 stimulates the proliferation of memory T cells and the immunosenescence is characterized by accumulation of memory T cells and exhaustion of naive T cells, we analyzed IL-15 levels in sera from 30 ultralongeval subjects with respect to those from young and old adults. IL-15 levels were assayed by immunoenzymaticmethods. Ultralongeval subjects displayed significantly higher IL-15 levels with respect to both young and old controls. No statistical difference was found between old and young controls. These findings may explain, at least in part, the characteristic increase of memory cells in immunosenescence and the capacity of the immune system of centenarians to defend itself from infections through immune-inflammatory responses.
AB - Aging is associated to a progressive establishing of a chronic inflammatory state linked to a continuous long exposure to antigens. Since IL-15 stimulates the proliferation of memory T cells and the immunosenescence is characterized by accumulation of memory T cells and exhaustion of naive T cells, we analyzed IL-15 levels in sera from 30 ultralongeval subjects with respect to those from young and old adults. IL-15 levels were assayed by immunoenzymaticmethods. Ultralongeval subjects displayed significantly higher IL-15 levels with respect to both young and old controls. No statistical difference was found between old and young controls. These findings may explain, at least in part, the characteristic increase of memory cells in immunosenescence and the capacity of the immune system of centenarians to defend itself from infections through immune-inflammatory responses.
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U2 - 10.1155/MI.2005.245
DO - 10.1155/MI.2005.245
M3 - Article
C2 - 16192677
AN - SCOPUS:25644432665
VL - 2005
SP - 245
EP - 247
JO - Mediators of Inflammation
JF - Mediators of Inflammation
SN - 0962-9351
IS - 4
ER -