Age-related modifications in circulating IL-15 levels in humans

Sebastiano Gangemi; Giorgio Basile; Daniela Monti; Rosaria Alba Merendino; Giuseppe Di Pasquale; Ursula Bisignano; Vittorio Nicita-Mauro; Claudio Franceschi

doi:10.1155/MI.2005.245

Age-related modifications in circulating IL-15 levels in humans

Sebastiano Gangemi, Giorgio Basile, Daniela Monti, Rosaria Alba Merendino, Giuseppe Di Pasquale, Ursula Bisignano, Vittorio Nicita-Mauro, Claudio Franceschi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Aging is associated to a progressive establishing of a chronic inflammatory state linked to a continuous long exposure to antigens. Since IL-15 stimulates the proliferation of memory T cells and the immunosenescence is characterized by accumulation of memory T cells and exhaustion of naive T cells, we analyzed IL-15 levels in sera from 30 ultralongeval subjects with respect to those from young and old adults. IL-15 levels were assayed by immunoenzymaticmethods. Ultralongeval subjects displayed significantly higher IL-15 levels with respect to both young and old controls. No statistical difference was found between old and young controls. These findings may explain, at least in part, the characteristic increase of memory cells in immunosenescence and the capacity of the immune system of centenarians to defend itself from infections through immune-inflammatory responses.

Original language	English
Pages (from-to)	245-247
Number of pages	3
Journal	Mediators of Inflammation
Volume	2005
Issue number	4
DOIs	https://doi.org/10.1155/MI.2005.245
Publication status	Published - Aug 31 2005

ASJC Scopus subject areas

Immunology
Cell Biology

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Age-related modifications in circulating IL-15 levels in humans. / Gangemi, Sebastiano; Basile, Giorgio; Monti, Daniela; Merendino, Rosaria Alba; Di Pasquale, Giuseppe; Bisignano, Ursula; Nicita-Mauro, Vittorio; Franceschi, Claudio.

In: Mediators of Inflammation, Vol. 2005, No. 4, 31.08.2005, p. 245-247.

Research output: Contribution to journal › Article › peer-review

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AU - Nicita-Mauro, Vittorio

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