Age-related prevalence of platelet-associated immunoglobulins G in nonthrombocytopenic patients with autoimmune thyroid disease and autoimmune polyglandular syndrome

L. Gargano, D. Mentuccia, L. Conti, N. Viceconti, R. Sibilla, D. Danese, F. S. Celi, G. Gandolfo, Marco Centanni

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The prevalence of platelet-associated IgG (paIgG) in nonthrombocytopenic patients with autoimmune thyroid disease (AITD) alone or associated with autoimmune polyglandular syndrome (APS) has been studied. Subjects: A total of 164 individuals were enrolled in this study: 81 patients with AITD alone, 33 patients with APS, and 50 healthy controls. Results: The presence of paIgG was recorded in 41 of 81 patients with AITD (51%) as compared with 2 of 50 control subjects (4%, <0.0001). The prevalence of paIgG in patients with APS was higher even when compared with patients with AITD alone (25/33, 76%; p = 0.02). The presence of paIgG was not related to the functional thyroid parameters. The prevalence of paIgG was higher in the older than in the younger patients (75 vs. 47%, p = 0.0037). Conclusions: The results indicate that the prevalence of paIgG in patients with AITD is higher than previously thought, namely in elderly patients and in patients with APS, and not related to the thyroid function.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalHormone Research
Volume56
Issue number5-6
DOIs
Publication statusPublished - 2001

Keywords

  • Autoimmune polyendocrine syndrome
  • Autoimmunity
  • Peroxidase
  • Platelets
  • Thyroid

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Age-related prevalence of platelet-associated immunoglobulins G in nonthrombocytopenic patients with autoimmune thyroid disease and autoimmune polyglandular syndrome'. Together they form a unique fingerprint.

Cite this