Age related prevalence of severe left ventricular hypertrophy in essential hypertension

Echocardiographic findings from the ETODH study

Cesare Cuspidi, Stefano Meani, Carla Sala, Cristiana Valerio, Francesca Negri, Giuseppe Mancia

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aim. We sought to investigate the prevalence and correlates of severe left ventricular hypertrophy (LVH) in relation to age in a large cohort of essential hypertensives referred to a single outpatient hypertension clinic. Methods. A total of 3752 (mean age 53±13 years, 53% men) untreated (29.5%) and treated hypertensive patients categorized in three age groups (I: 18-40 years; II: 41-64 years; III: ≥65 years) were considered for this analysis. All patients underwent extensive investigations searching for target organ damage. LVH, defined as LV mass ≥49/45 g/m 2.7 in men/women, respectively, was graded as mild, moderate and severe according to Lang's report. Results. LVH prevalence was 29.4% in group I, 48.2% in group II and 63.6% in group III. Overall, more than one fourth of patients with LVH had a severely increased LV mass index; the likelihood of having severe LVH was two- and four-fold higher in elderly hypertensives than in their middle-aged and young counterparts, respectively. Increasing age and LVH degree were both associated with a greater prevalence of concentric LV geometry as well as of extra-cardiac organ damage (i.e. carotid intima-media thickness). Conclusions. LVH is a highly prevalent organ damage in essential hypertensives, particularly in the elderly, who exhibited a more severe increase of LV mass index, higher relative wall thickness and extra-cardiac organ damage compared with young and middle-aged sub-groups. Our findings suggest that the assessment of cardiovascular risk by grading LVH rather than simply defining the presence/absence of this cardiac phenotype could improve therapeutic strategies in the hypertensive population, particularly in the elderly.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalBlood Pressure
Volume21
Issue number3
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Left Ventricular Hypertrophy
Carotid Intima-Media Thickness
Essential Hypertension
Ambulatory Care Facilities
Age Groups
Hypertension
Phenotype
Population

Keywords

  • echocardiography
  • elderly
  • hypertension
  • severe left ventricular hypertrophy

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Age related prevalence of severe left ventricular hypertrophy in essential hypertension : Echocardiographic findings from the ETODH study. / Cuspidi, Cesare; Meani, Stefano; Sala, Carla; Valerio, Cristiana; Negri, Francesca; Mancia, Giuseppe.

In: Blood Pressure, Vol. 21, No. 3, 06.2012, p. 139-145.

Research output: Contribution to journalArticle

Cuspidi, Cesare ; Meani, Stefano ; Sala, Carla ; Valerio, Cristiana ; Negri, Francesca ; Mancia, Giuseppe. / Age related prevalence of severe left ventricular hypertrophy in essential hypertension : Echocardiographic findings from the ETODH study. In: Blood Pressure. 2012 ; Vol. 21, No. 3. pp. 139-145.
@article{c767eb15d35341759eb81670e6510f57,
title = "Age related prevalence of severe left ventricular hypertrophy in essential hypertension: Echocardiographic findings from the ETODH study",
abstract = "Aim. We sought to investigate the prevalence and correlates of severe left ventricular hypertrophy (LVH) in relation to age in a large cohort of essential hypertensives referred to a single outpatient hypertension clinic. Methods. A total of 3752 (mean age 53±13 years, 53{\%} men) untreated (29.5{\%}) and treated hypertensive patients categorized in three age groups (I: 18-40 years; II: 41-64 years; III: ≥65 years) were considered for this analysis. All patients underwent extensive investigations searching for target organ damage. LVH, defined as LV mass ≥49/45 g/m 2.7 in men/women, respectively, was graded as mild, moderate and severe according to Lang's report. Results. LVH prevalence was 29.4{\%} in group I, 48.2{\%} in group II and 63.6{\%} in group III. Overall, more than one fourth of patients with LVH had a severely increased LV mass index; the likelihood of having severe LVH was two- and four-fold higher in elderly hypertensives than in their middle-aged and young counterparts, respectively. Increasing age and LVH degree were both associated with a greater prevalence of concentric LV geometry as well as of extra-cardiac organ damage (i.e. carotid intima-media thickness). Conclusions. LVH is a highly prevalent organ damage in essential hypertensives, particularly in the elderly, who exhibited a more severe increase of LV mass index, higher relative wall thickness and extra-cardiac organ damage compared with young and middle-aged sub-groups. Our findings suggest that the assessment of cardiovascular risk by grading LVH rather than simply defining the presence/absence of this cardiac phenotype could improve therapeutic strategies in the hypertensive population, particularly in the elderly.",
keywords = "echocardiography, elderly, hypertension, severe left ventricular hypertrophy",
author = "Cesare Cuspidi and Stefano Meani and Carla Sala and Cristiana Valerio and Francesca Negri and Giuseppe Mancia",
year = "2012",
month = "6",
doi = "10.3109/08037051.2012.668662",
language = "English",
volume = "21",
pages = "139--145",
journal = "Blood Pressure",
issn = "0803-7051",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Age related prevalence of severe left ventricular hypertrophy in essential hypertension

T2 - Echocardiographic findings from the ETODH study

AU - Cuspidi, Cesare

AU - Meani, Stefano

AU - Sala, Carla

AU - Valerio, Cristiana

AU - Negri, Francesca

AU - Mancia, Giuseppe

PY - 2012/6

Y1 - 2012/6

N2 - Aim. We sought to investigate the prevalence and correlates of severe left ventricular hypertrophy (LVH) in relation to age in a large cohort of essential hypertensives referred to a single outpatient hypertension clinic. Methods. A total of 3752 (mean age 53±13 years, 53% men) untreated (29.5%) and treated hypertensive patients categorized in three age groups (I: 18-40 years; II: 41-64 years; III: ≥65 years) were considered for this analysis. All patients underwent extensive investigations searching for target organ damage. LVH, defined as LV mass ≥49/45 g/m 2.7 in men/women, respectively, was graded as mild, moderate and severe according to Lang's report. Results. LVH prevalence was 29.4% in group I, 48.2% in group II and 63.6% in group III. Overall, more than one fourth of patients with LVH had a severely increased LV mass index; the likelihood of having severe LVH was two- and four-fold higher in elderly hypertensives than in their middle-aged and young counterparts, respectively. Increasing age and LVH degree were both associated with a greater prevalence of concentric LV geometry as well as of extra-cardiac organ damage (i.e. carotid intima-media thickness). Conclusions. LVH is a highly prevalent organ damage in essential hypertensives, particularly in the elderly, who exhibited a more severe increase of LV mass index, higher relative wall thickness and extra-cardiac organ damage compared with young and middle-aged sub-groups. Our findings suggest that the assessment of cardiovascular risk by grading LVH rather than simply defining the presence/absence of this cardiac phenotype could improve therapeutic strategies in the hypertensive population, particularly in the elderly.

AB - Aim. We sought to investigate the prevalence and correlates of severe left ventricular hypertrophy (LVH) in relation to age in a large cohort of essential hypertensives referred to a single outpatient hypertension clinic. Methods. A total of 3752 (mean age 53±13 years, 53% men) untreated (29.5%) and treated hypertensive patients categorized in three age groups (I: 18-40 years; II: 41-64 years; III: ≥65 years) were considered for this analysis. All patients underwent extensive investigations searching for target organ damage. LVH, defined as LV mass ≥49/45 g/m 2.7 in men/women, respectively, was graded as mild, moderate and severe according to Lang's report. Results. LVH prevalence was 29.4% in group I, 48.2% in group II and 63.6% in group III. Overall, more than one fourth of patients with LVH had a severely increased LV mass index; the likelihood of having severe LVH was two- and four-fold higher in elderly hypertensives than in their middle-aged and young counterparts, respectively. Increasing age and LVH degree were both associated with a greater prevalence of concentric LV geometry as well as of extra-cardiac organ damage (i.e. carotid intima-media thickness). Conclusions. LVH is a highly prevalent organ damage in essential hypertensives, particularly in the elderly, who exhibited a more severe increase of LV mass index, higher relative wall thickness and extra-cardiac organ damage compared with young and middle-aged sub-groups. Our findings suggest that the assessment of cardiovascular risk by grading LVH rather than simply defining the presence/absence of this cardiac phenotype could improve therapeutic strategies in the hypertensive population, particularly in the elderly.

KW - echocardiography

KW - elderly

KW - hypertension

KW - severe left ventricular hypertrophy

UR - http://www.scopus.com/inward/record.url?scp=84860880784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860880784&partnerID=8YFLogxK

U2 - 10.3109/08037051.2012.668662

DO - 10.3109/08037051.2012.668662

M3 - Article

VL - 21

SP - 139

EP - 145

JO - Blood Pressure

JF - Blood Pressure

SN - 0803-7051

IS - 3

ER -