Age-related standards for T lymphocyte subsets based on uninfected children born to human immunodeficiency virus 1-infected women

C. Giaquinto, F. Zacchello, A. De Rossi, L. Chieco Bianchi, I. Grosch Wörner, M. Vocks Hauck, J. Y Q Mok, A. G. Bird, F. Omeñaca Teres, M. C. Garcia Rodriguez, R. Jmartinez Zapico, M. I. De Jose, G. Fontan, A. Ferreira, C. A. Canosa, H. J. Scherpbier, M. Roos, A. B. Bohlin, A. Ferrazin, C. GottaD. Bassetti, J. Levy, A. Mur, H. Yazbeck, J. Llorens-Terol

Research output: Contribution to journalArticle

Abstract

The T lymphocyte subsets in the peripheral blood of 459 uninfected children born to white human immunodeficiency virus 1-infected women included in the European Collaborative Study were measured at regular intervals from birth. More than 2400 observations were used to create smooth age-related reference ranges for CD4 and CD8 counts and percentages, CD4:CD8 ratio and absolute lymphocyte count. Standards are presented for children up to 4 years of age. CD4, CD8 and absolute lymphocyte count rose after birth, peaked at around 6 to 9 months of age and then declined toward adult values. CD4 percentage and CD4:CD8 ratio declined steadily from birth onwards. Centile lines for CD4 count and CD4:CD8 ratio converged markedly with age. For the CD4 values, only 3 to 5% of the variation was attributable to differences between the 10 participating centers. These standards allow T lymphocyte abnormalities to be used more effectively as markers for disease progression and assist in the clinical follow up of human immunodeficiency virus 1-infected children. They also provide a basis for initiating antiretroviral treatment or antimicrobial prophylaxis.

Original languageEnglish
Pages (from-to)1018-1026
Number of pages9
JournalPediatric Infectious Disease Journal
Volume11
Issue number12
Publication statusPublished - 1992

Keywords

  • Age-related standards
  • Human immunodeficiency virus-exposed
  • T lymphocyte subsets

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Pediatrics, Perinatology, and Child Health

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    Giaquinto, C., Zacchello, F., De Rossi, A., Chieco Bianchi, L., Grosch Wörner, I., Vocks Hauck, M., Mok, J. Y. Q., Bird, A. G., Omeñaca Teres, F., Garcia Rodriguez, M. C., Jmartinez Zapico, R., De Jose, M. I., Fontan, G., Ferreira, A., Canosa, C. A., Scherpbier, H. J., Roos, M., Bohlin, A. B., Ferrazin, A., ... Llorens-Terol, J. (1992). Age-related standards for T lymphocyte subsets based on uninfected children born to human immunodeficiency virus 1-infected women. Pediatric Infectious Disease Journal, 11(12), 1018-1026.