Abstract
The T lymphocyte subsets in the peripheral blood of 459 uninfected children born to white human immunodeficiency virus 1-infected women included in the European Collaborative Study were measured at regular intervals from birth. More than 2400 observations were used to create smooth age-related reference ranges for CD4 and CD8 counts and percentages, CD4:CD8 ratio and absolute lymphocyte count. Standards are presented for children up to 4 years of age. CD4, CD8 and absolute lymphocyte count rose after birth, peaked at around 6 to 9 months of age and then declined toward adult values. CD4 percentage and CD4:CD8 ratio declined steadily from birth onwards. Centile lines for CD4 count and CD4:CD8 ratio converged markedly with age. For the CD4 values, only 3 to 5% of the variation was attributable to differences between the 10 participating centers. These standards allow T lymphocyte abnormalities to be used more effectively as markers for disease progression and assist in the clinical follow up of human immunodeficiency virus 1-infected children. They also provide a basis for initiating antiretroviral treatment or antimicrobial prophylaxis.
| Original language | English |
|---|---|
| Pages (from-to) | 1018-1026 |
| Number of pages | 9 |
| Journal | Pediatric Infectious Disease Journal |
| Volume | 11 |
| Issue number | 12 |
| Publication status | Published - 1992 |
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Keywords
- Age-related standards
- Human immunodeficiency virus-exposed
- T lymphocyte subsets
ASJC Scopus subject areas
- Infectious Diseases
- Microbiology (medical)
- Pediatrics, Perinatology, and Child Health
Cite this
Age-related standards for T lymphocyte subsets based on uninfected children born to human immunodeficiency virus 1-infected women. / Giaquinto, C.; Zacchello, F.; De Rossi, A.; Chieco Bianchi, L.; Grosch Wörner, I.; Vocks Hauck, M.; Mok, J. Y Q; Bird, A. G.; Omeñaca Teres, F.; Garcia Rodriguez, M. C.; Jmartinez Zapico, R.; De Jose, M. I.; Fontan, G.; Ferreira, A.; Canosa, C. A.; Scherpbier, H. J.; Roos, M.; Bohlin, A. B.; Ferrazin, A.; Gotta, C.; Bassetti, D.; Levy, J.; Mur, A.; Yazbeck, H.; Llorens-Terol, J.
In: Pediatric Infectious Disease Journal, Vol. 11, No. 12, 1992, p. 1018-1026.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-related standards for T lymphocyte subsets based on uninfected children born to human immunodeficiency virus 1-infected women
AU - Giaquinto, C.
AU - Zacchello, F.
AU - De Rossi, A.
AU - Chieco Bianchi, L.
AU - Grosch Wörner, I.
AU - Vocks Hauck, M.
AU - Mok, J. Y Q
AU - Bird, A. G.
AU - Omeñaca Teres, F.
AU - Garcia Rodriguez, M. C.
AU - Jmartinez Zapico, R.
AU - De Jose, M. I.
AU - Fontan, G.
AU - Ferreira, A.
AU - Canosa, C. A.
AU - Scherpbier, H. J.
AU - Roos, M.
AU - Bohlin, A. B.
AU - Ferrazin, A.
AU - Gotta, C.
AU - Bassetti, D.
AU - Levy, J.
AU - Mur, A.
AU - Yazbeck, H.
AU - Llorens-Terol, J.
PY - 1992
Y1 - 1992
N2 - The T lymphocyte subsets in the peripheral blood of 459 uninfected children born to white human immunodeficiency virus 1-infected women included in the European Collaborative Study were measured at regular intervals from birth. More than 2400 observations were used to create smooth age-related reference ranges for CD4 and CD8 counts and percentages, CD4:CD8 ratio and absolute lymphocyte count. Standards are presented for children up to 4 years of age. CD4, CD8 and absolute lymphocyte count rose after birth, peaked at around 6 to 9 months of age and then declined toward adult values. CD4 percentage and CD4:CD8 ratio declined steadily from birth onwards. Centile lines for CD4 count and CD4:CD8 ratio converged markedly with age. For the CD4 values, only 3 to 5% of the variation was attributable to differences between the 10 participating centers. These standards allow T lymphocyte abnormalities to be used more effectively as markers for disease progression and assist in the clinical follow up of human immunodeficiency virus 1-infected children. They also provide a basis for initiating antiretroviral treatment or antimicrobial prophylaxis.
AB - The T lymphocyte subsets in the peripheral blood of 459 uninfected children born to white human immunodeficiency virus 1-infected women included in the European Collaborative Study were measured at regular intervals from birth. More than 2400 observations were used to create smooth age-related reference ranges for CD4 and CD8 counts and percentages, CD4:CD8 ratio and absolute lymphocyte count. Standards are presented for children up to 4 years of age. CD4, CD8 and absolute lymphocyte count rose after birth, peaked at around 6 to 9 months of age and then declined toward adult values. CD4 percentage and CD4:CD8 ratio declined steadily from birth onwards. Centile lines for CD4 count and CD4:CD8 ratio converged markedly with age. For the CD4 values, only 3 to 5% of the variation was attributable to differences between the 10 participating centers. These standards allow T lymphocyte abnormalities to be used more effectively as markers for disease progression and assist in the clinical follow up of human immunodeficiency virus 1-infected children. They also provide a basis for initiating antiretroviral treatment or antimicrobial prophylaxis.
KW - Age-related standards
KW - Human immunodeficiency virus-exposed
KW - T lymphocyte subsets
UR - http://www.scopus.com/inward/record.url?scp=0026454728&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026454728&partnerID=8YFLogxK
M3 - Article
C2 - 1361051
AN - SCOPUS:0026454728
VL - 11
SP - 1018
EP - 1026
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
SN - 0891-3668
IS - 12
ER -