Age-related ultrastructural and monoamine oxidase changes in the rat optic nerve

Samanta Taurone, G. Ripandelli, Antonio Minni, Riccardo Lattanzi, A. S. Miglietta, N. Pepe, L. Fumagalli, A. Micera, F. S. Pastore, Marco Artico

Research output: Contribution to journalArticlepeer-review


The aim of this paper is to study the morphology and the distribution of the monoamine oxidase enzymatic system in the optic nerve of 4 month-old Wistar (young) and 28 month-old Wistar (old) rats. The optic nerve was harvested from 20 young and old rats. The segment of optic nerve was divided longitudinally into two pieces, each 0.1 mm in length. The first piece was used for transmission electron microscopy. The second piece was stained with histochemical reaction for monoamine oxidase. The age-related changes in the optic nerve of rats include micro-anatomical details, ultrastructure and monoamine oxidase histochemical staining. A strong decrease of the thin nerve fibers and a swelling of the thick ones can be observed in optic nerve fibers of old rats. Increased monoamine oxidase histochemical staining of the optic nerve of aged rats is well demonstrated. The increase of meningeal shealth and the decrease of thin nerve fibers of the optic nerve in old rats are well documented. Morphological, ultrastructural and histochemical changes observed in optic nerve fibers of the old rats show a close relation with aging.

Original languageEnglish
Pages (from-to)903-908
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number3
Publication statusPublished - 2016


  • Age-related changes
  • Histochemistry
  • Light microscopy
  • MAO enzymes
  • Optic nerve
  • Transmission electron miavscopy

ASJC Scopus subject areas

  • Medicine(all)


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