Age-releated changes in Cu,Zn superoxide dismutase, Se-dependent and -independent glutathione peroxidase and catalase activities in specific areas of rat brain

M. R. Ciriolo, K. Fiskin, A. De Martino, M. T. Corasaniti, G. Nistico, G. Rotilio

Research output: Contribution to journalArticle

Abstract

Oxidative injury of tissues involves both accumulation of damage due to persistent oxidative stress and loss of the proper balance of antioxidative enzymes. These events may produce a faster rate of tissue senescence. In this regard, we have assayed the antioxidative enzyme activities (Cu,Zn superoxide dismutase, glutathione peroxidase and catalase), in various areas of rat brain (prefrontal cortex, parietal cortex, hippocampus, hypothalamus, caudate nucleus, mesencephalon and lower brain stem) for the age groups of 3, 6, 12, 24 months. The results obtained show that the levels of antioxidant enzyme activities differed considerably in the various brain parts studied. Furthermore, changes in the specific activities of superoxide dismutase, catalase, and glutathione peroxidase did not follow the same pattern as a function of aging. In particular, in prefrontal cortex and caudate nucleus, superoxide dismutase and glutathione peroxidase activities did not change, while catalase activity decreased. In parietal cortex and mesencephalon, superoxide dismutase and glutathione peroxidase activities increased, but the catalase activity decreased in parietal cortex and did not change in mesencephalon. In lower brain stem, the activities of glutathione peroxidase and catalase decreased in 3-12-month-old rats. The activity of glutathione peroxidase was increased in the hippocampus and was decreased in hypothalamus during aging. In this area the catalase activity was also significantly diminished.

Original languageEnglish
Pages (from-to)287-297
Number of pages11
JournalMechanisms of Ageing and Development
Volume61
Issue number3
DOIs
Publication statusPublished - Dec 31 1991

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Glutathione Peroxidase
Catalase
Rats
Brain
Parietal Lobe
Mesencephalon
Superoxide Dismutase
Caudate Nucleus
Enzyme activity
Prefrontal Cortex
Hypothalamus
Brain Stem
Hippocampus
Enzymes
Aging of materials
Tissue
Oxidative stress
Superoxide Dismutase-1
Oxidative Stress
Age Groups

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Age-releated changes in Cu,Zn superoxide dismutase, Se-dependent and -independent glutathione peroxidase and catalase activities in specific areas of rat brain. / Ciriolo, M. R.; Fiskin, K.; De Martino, A.; Corasaniti, M. T.; Nistico, G.; Rotilio, G.

In: Mechanisms of Ageing and Development, Vol. 61, No. 3, 31.12.1991, p. 287-297.

Research output: Contribution to journalArticle

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