Age, sex and mental retardation related changes of brainstem auditory evoked potentials in Down's syndrome.

R. Ferri, S. Del Gracco, M. Elia, S. A. Musumeci, M. C. Stefanini

Research output: Contribution to journalArticle

Abstract

Brainstem auditory evoked potentials (BAEPs) were recorded in 51 Down's syndrome (DS) subjects and compared with those of 38 normal controls; the correlations between the BAEP measures and age, sex, and degree of mental retardation were then evaluated. The DS patients showed a significant reduction in wave V latency and amplitude and in I-III, III-V, and I-V interpeak intervals. An age-related shortening of the I-V interpeak interval found in DS patients was interpreted as being a result of changes in central inhibitory/excitatory mechanisms. In both groups, female subjects presented an I-V interval shorter than that of males but this difference was greater in the DS subjects than in the normal population. The DS patients with severe mental retardation showed significantly longer I-V interpeak intervals than those with moderate retardation; this could be due to the presence of additional central nervous system abnormalities.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalItalian Journal of Neurological Sciences
Volume16
Issue number6
Publication statusPublished - Sep 1995

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Brain Stem Auditory Evoked Potentials
Down Syndrome
Intellectual Disability
Nervous System Malformations
Central Nervous System
Population

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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Age, sex and mental retardation related changes of brainstem auditory evoked potentials in Down's syndrome. / Ferri, R.; Del Gracco, S.; Elia, M.; Musumeci, S. A.; Stefanini, M. C.

In: Italian Journal of Neurological Sciences, Vol. 16, No. 6, 09.1995, p. 377-383.

Research output: Contribution to journalArticle

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