Age, sex and mental retardation related changes of brainstem auditory evoked potentials in Down's syndrome

R. Ferri, S. Del Gracco, M. Elia, S. A. Musumeci, M. C. Stefanini

Research output: Contribution to journalArticle

Abstract

Brainstem auditory evoked potentials (BAEPs) were recorded in 51 Down's syndrome (DS) subjects and compared with those of 38 normal controls; the correlations between the BAEP measures and age, sex, and degree of mental retardation were then evaluated. The DS patients showed a significant reduction in wave V latency and amplitude and in I-III, III-V, and I-V interpeak intervals. An age-related shortening of the I-V interpeak interval found in DS patients was interpreted as being a result of changes in central inhibitory/excitatory mechanisms. In both groups, female subjects presented an I-V interval shorter than that of males but this difference was greater in the DS subjects than in the normal population. The DS patients with severe mental retardation showed significantly longer I-V interpeak intervals than those with moderate retardation; this could be due to the presence of additional central nervous system abnormalities.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalItalian Journal of Neurological Sciences
Volume16
Issue number5
DOIs
Publication statusPublished - Jun 1995

Keywords

  • age
  • brainstem auditory evoked potentials
  • Down's syndrome
  • mental retardation
  • sex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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